Matrix metalloproteinase (MMP)-3 activates MMP-9 mediated vascular smooth muscle cell migration and neointima formation in mice

Jason L Johnson; Amrita Dwivedi; Michelle Somerville; Sarah J George; Andrew C Newby

doi:10.1161/ATVBAHA.111.225623

Matrix metalloproteinase (MMP)-3 activates MMP-9 mediated vascular smooth muscle cell migration and neointima formation in mice

Jason L Johnson, Amrita Dwivedi, Michelle Somerville, Sarah J George, Andrew C Newby

Research output: Contribution to journal › Article (Academic Journal) › peer-review

136 Citations (Scopus)

Abstract

OBJECTIVE: Several matrix metalloproteinases (MMPs) have been implicated in extracellular matrix destruction and other actions that lead to plaque rupture and myocardial infarction. Conversely, other MMPs have been shown to promote vascular smooth muscle cell (VSMC)-driven neointima formation, which contributes to restenosis, fibrous cap formation, and plaque stability. MMP-3 knockout reduced VSMC accumulation in mouse atherosclerotic plaques, implicating MMP-3 in neointima formation. We therefore investigated the effect of MMP-3 knockout on neointima formation after carotid ligation in vivo and VSMC migration in vitro. METHODS AND RESULTS: Twenty-eight days after left carotid ligation, MMP-3 knockout significantly reduced neointima formation (75%, P

Translated title of the contribution	Matrix Metalloproteinase (MMP)-3 Activates MMP-9 Mediated Vascular Smooth Muscle Cell Migration and Neointima Formation in Mice
Original language	English
Pages (from-to)	e35 - e44
Number of pages	10
Journal	Arteriosclerosis, Thrombosis, and Vascular Biology
Volume	31
Issue number	9
Early online date	30 Jun 2011
DOIs	https://doi.org/10.1161/ATVBAHA.111.225623
Publication status	Published - Sept 2011

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http://atvb.ahajournals.org/content/31/9/e35

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@article{76767a5a7be345e5afc915650442d0d2,

title = "Matrix metalloproteinase (MMP)-3 activates MMP-9 mediated vascular smooth muscle cell migration and neointima formation in mice",

abstract = "OBJECTIVE: Several matrix metalloproteinases (MMPs) have been implicated in extracellular matrix destruction and other actions that lead to plaque rupture and myocardial infarction. Conversely, other MMPs have been shown to promote vascular smooth muscle cell (VSMC)-driven neointima formation, which contributes to restenosis, fibrous cap formation, and plaque stability. MMP-3 knockout reduced VSMC accumulation in mouse atherosclerotic plaques, implicating MMP-3 in neointima formation. We therefore investigated the effect of MMP-3 knockout on neointima formation after carotid ligation in vivo and VSMC migration in vitro. METHODS AND RESULTS: Twenty-eight days after left carotid ligation, MMP-3 knockout significantly reduced neointima formation (75\%, P",

author = "Johnson, \{Jason L\} and Amrita Dwivedi and Michelle Somerville and George, \{Sarah J\} and Newby, \{Andrew C\}",

year = "2011",

month = sep,

doi = "10.1161/ATVBAHA.111.225623",

language = "English",

volume = "31",

pages = "e35 -- e44",

journal = "Arteriosclerosis, Thrombosis, and Vascular Biology",

issn = "1079-5642",

publisher = "Lippincott Williams and Wilkins",

number = "9",

}

Matrix metalloproteinase (MMP)-3 activates MMP-9 mediated vascular smooth muscle cell migration and neointima formation in mice. / Johnson, Jason L; Dwivedi, Amrita; Somerville, Michelle et al.
In: Arteriosclerosis, Thrombosis, and Vascular Biology, Vol. 31, No. 9, 09.2011, p. e35 - e44.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

TY - JOUR

T1 - Matrix metalloproteinase (MMP)-3 activates MMP-9 mediated vascular smooth muscle cell migration and neointima formation in mice

AU - Johnson, Jason L

AU - Dwivedi, Amrita

AU - Somerville, Michelle

AU - George, Sarah J

AU - Newby, Andrew C

PY - 2011/9

Y1 - 2011/9

N2 - OBJECTIVE: Several matrix metalloproteinases (MMPs) have been implicated in extracellular matrix destruction and other actions that lead to plaque rupture and myocardial infarction. Conversely, other MMPs have been shown to promote vascular smooth muscle cell (VSMC)-driven neointima formation, which contributes to restenosis, fibrous cap formation, and plaque stability. MMP-3 knockout reduced VSMC accumulation in mouse atherosclerotic plaques, implicating MMP-3 in neointima formation. We therefore investigated the effect of MMP-3 knockout on neointima formation after carotid ligation in vivo and VSMC migration in vitro. METHODS AND RESULTS: Twenty-eight days after left carotid ligation, MMP-3 knockout significantly reduced neointima formation (75%, P

AB - OBJECTIVE: Several matrix metalloproteinases (MMPs) have been implicated in extracellular matrix destruction and other actions that lead to plaque rupture and myocardial infarction. Conversely, other MMPs have been shown to promote vascular smooth muscle cell (VSMC)-driven neointima formation, which contributes to restenosis, fibrous cap formation, and plaque stability. MMP-3 knockout reduced VSMC accumulation in mouse atherosclerotic plaques, implicating MMP-3 in neointima formation. We therefore investigated the effect of MMP-3 knockout on neointima formation after carotid ligation in vivo and VSMC migration in vitro. METHODS AND RESULTS: Twenty-eight days after left carotid ligation, MMP-3 knockout significantly reduced neointima formation (75%, P

UR - https://www.scopus.com/pages/publications/80052137568

U2 - 10.1161/ATVBAHA.111.225623

DO - 10.1161/ATVBAHA.111.225623

M3 - Article (Academic Journal)

C2 - 21719762

SN - 1079-5642

VL - 31

SP - e35 - e44

JO - Arteriosclerosis, Thrombosis, and Vascular Biology

JF - Arteriosclerosis, Thrombosis, and Vascular Biology

IS - 9

ER -

Matrix metalloproteinase (MMP)-3 activates MMP-9 mediated vascular smooth muscle cell migration and neointima formation in mice

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