Measuring Biomolecular Binding Events with a Compact Disc Player Device

SA Lange, G Roth, S Wittemann, T Lacoste, A Vetter, J Grässle, S Kopta, M Kolleck, B Breitinger, M Wick, JKH Hoerber, S Dubel, A Bernard

Research output: Contribution to journalArticle (Academic Journal)

57 Citations (Scopus)

Abstract

Read the fine print: Biomolecular binding events can be counted with a readout system based on compact disc (CD) pickup technology. An immunoassay of C-reactive protein was performed by microcontact printing of antibodies onto a support, autometallography, and imaging by a CD reader mounted on an optical microscope (see picture). The dynamic range was four orders of magnitude with a detection limit of 1 pM.
Translated title of the contributionMeasuring Biomolecular Binding Events with a Compact Disc Player Device
Original languageEnglish
Pages (from-to)270-273
Number of pages4
JournalAngewandte Chemie - International Edition
Volume45
Issue number2
Early online date21 Dec 2005
DOIs
Publication statusPublished - Dec 2005

Bibliographical note

Publisher: Wiley

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  • Cite this

    Lange, SA., Roth, G., Wittemann, S., Lacoste, T., Vetter, A., Grässle, J., Kopta, S., Kolleck, M., Breitinger, B., Wick, M., Hoerber, JKH., Dubel, S., & Bernard, A. (2005). Measuring Biomolecular Binding Events with a Compact Disc Player Device. Angewandte Chemie - International Edition, 45(2), 270-273. https://doi.org/10.1002/anie.200501243