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Measuring Biomolecular Binding Events with a Compact Disc Player Device

Research output: Contribution to journalArticle

  • SA Lange
  • G Roth
  • S Wittemann
  • T Lacoste
  • A Vetter
  • J Grässle
  • S Kopta
  • M Kolleck
  • B Breitinger
  • M Wick
  • JKH Hoerber
  • S Dubel
  • A Bernard
Original languageEnglish
Pages (from-to)270-273
Number of pages4
JournalAngewandte Chemie - International Edition
Issue number2
Early online date21 Dec 2005
DateE-pub ahead of print - 21 Dec 2005
DatePublished (current) - Dec 2005


Read the fine print: Biomolecular binding events can be counted with a readout system based on compact disc (CD) pickup technology. An immunoassay of C-reactive protein was performed by microcontact printing of antibodies onto a support, autometallography, and imaging by a CD reader mounted on an optical microscope (see picture). The dynamic range was four orders of magnitude with a detection limit of 1 pM.

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Publisher: Wiley



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