Mechanisms for inducing nasal mucosal tolerance in Experimental Autoimmune Uveoretinitis (EAU)

CJ Calder, LB Nicholson, AD Dick

Research output: Contribution to journalArticle (Academic Journal)peer-review

7 Citations (Scopus)

Abstract

Delivering soluble (auto) antigenic peptides via the naso-respiratory route induces tolerance to that peptide and suppression of experimental models of autoimmune disease. In the normal lung, respiratory tract dendritic cells (RTDCs) efficiently endocytose soluble antigens, migrate to regional lymph nodes and present peptide to T cells that subsequently become tolerant. This article describes protocols for inducing tolerance via the naso-respiratory tract in experimental autoimmune uveoretinitis (EAU); for the isolation of RTDCs to facilitate definition of, and conditions for, maturation and activation of cells; and to test RTDC ability to induce tolerance in murine EAU when adoptively transferred.
Translated title of the contributionMechanisms for inducing nasal mucosal tolerance in Experimental Autoimmune Uveoretinitis (EAU)
Original languageEnglish
Pages (from-to)69 - 76
Number of pages8
JournalMethods
Volume38 (2)
DOIs
Publication statusPublished - Feb 2006

Bibliographical note

Publisher: Elsevier

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