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Mechanisms in endocrinology: Does circadian and ultradian glucocorticoid exposure affect the brain?

Research output: Contribution to journalReview article

Original languageEnglish
Pages (from-to)R73-R89
Number of pages17
JournalEuropean Journal of Endocrinology
Issue number2
Early online date1 Feb 2019
DateAccepted/In press - 23 Nov 2018
DateE-pub ahead of print - 1 Feb 2019
DatePublished (current) - Feb 2019


Glucocorticoids are a class of systematically secreted hormones, vital for mammalian life, which are intensively investigated for more than 80 years. They regulate multiple bod y processes like metabolism, fluid homeostasis, immune and stress system responsivity, as well as brain functio n. Glucocorticoids have a complex rhythm by which they are released to circulation from the adrenal cortex. The h ormone exhibits a circadian variation, with high hormonal levels being secreted just prior and during the active part of the day, and progressively lower and lower amounts being released during the inactive part of it. Underlyi ng this diurnal variation there is a more dynamic, ultradian rhythm composed of frequent episodes of glucocorticoi d secretion (hormonal pulses). Accumulating evidence from observational, in silico, in vitro and in vivo, preclinical and clinical studies suggest that both aspects of glucocorticoid rhythmicity are preserved among mammalian spe cies and are important for brain function. The central nervous system is exposed to both aspects of the hormon al rhythm and has developed mechanisms able to perceive them and translate them to differential cellular eve nts, genomic and non-genomic. Thus, glucocorticoid rhythmicity regulates various physiological neural and glial pr ocesses, under baseline and stressful conditions, and hormonal dysrhythmicity has been associated with cognitive and behavioural defects. This raises a number of clinical implications concerning (i) glucocorticoid involvement in neuropsychiatric disease and (ii) improving the therapeutic efficacy or expanding the role of glucocorticoid-based treatments in such conditions.

    Research areas

  • glucocorticoid rhythmicity, brain function, circadian, ultradian

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    Rights statement: This is the author accepted manuscript (AAM). The final published version (version of record) is available online via BioScientifica at Please refer to any applicable terms of use of the publisher.

    Accepted author manuscript, 537 KB, PDF document


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