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Mechanisms of AMPA receptor endosomal sorting

Research output: Contribution to journalReview article

Original languageEnglish
Article number440
Number of pages15
JournalFrontiers in Molecular Neuroscience
Volume11
DOIs
DateAccepted/In press - 13 Nov 2018
DatePublished (current) - 5 Dec 2018

Abstract

The regulation of synaptic AMPA receptors (AMPARs) is critical for excitatory synaptic transmission, synaptic plasticity and the consequent formation of neural circuits during brain development and their modification during learning and memory processes. The number of synaptic AMPARs is regulated through endocytosis, exocytosis and endosomal sorting that results in recycling back to the plasma membrane or degradation in the lysosome. Hence, endo-lysosomal sorting is vitally important in maintaining AMPAR expression at the synapse, and the dynamic regulation of these trafficking events is a key component of synaptic plasticity. A reduction in synaptic strength such as in long-term depression (LTD) involves AMPAR sorting to lysosomes to reduce synaptic AMPAR number, whereas long-term potentiation (LTP) involves an increase in AMPAR recycling to increase the number of AMPARs at synapses. Here, we review our current understanding of the endosomal trafficking routes taken by AMPARs, and the mechanisms involved in AMPAR endosomal sorting, focussing on the numerous AMPAR associated proteins that have been implicated in this complex process. We also discuss how these events are dysregulated in brain disorders.

    Research areas

  • Endosome, Glutamate receptor, LTD (long term depression), LTP (long term potentiation), Synapse, Synaptic plasticity, Trafficking

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    Rights statement: This is the final published version of the article (version of record). It first appeared online via Frontiers Media at https://www.frontiersin.org/articles/10.3389/fnmol.2018.00440/full . Please refer to any applicable terms of use of the publisher.

    Final published version, 1.43 MB, PDF document

    Licence: CC BY

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