Medial prefrontal cortex circuitry and social behaviour in autism

Diego H. Mediane; Shinjini Basu; Emma N. Cahill; Paul G. Anastasiades

doi:10.1016/j.neuropharm.2024.110101

Medial prefrontal cortex circuitry and social behaviour in autism

Diego H. Mediane, Shinjini Basu, Emma N. Cahill, Paul G. Anastasiades^*

^*Corresponding author for this work

Research output: Contribution to journal › Article (Academic Journal) › peer-review

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Abstract

Autism spectrum disorder (ASD) has proven to be highly enigmatic due to the diversity of its underlying genetic causes and the huge variability in symptom presentation. Uncovering common phenotypes across people with ASD and pre-clinical models allows us to better understand the influence on brain function of the many different genetic and cellular processes thought to contribute to ASD aetiology. One such feature of ASD is the convergent evidence implicating abnormal functioning of the medial prefrontal cortex (mPFC) across studies. The mPFC is a key part of the 'social brain' and may contribute to many of the changes in social behaviour observed in people with ASD. Here we review recent evidence for mPFC involvement in both ASD and social behaviours. We also highlight how pre-clinical mouse models can be used to uncover important cellular and circuit-level mechanisms that may underly atypical social behaviours in ASD.

This article is part of the Special Issue on "PFC circuit function in psychiatric disease and relevant models".

Original language	English
Article number	110101
Number of pages	12
Journal	Neuropharmacology
Volume	260
Early online date	14 Aug 2024
DOIs	https://doi.org/10.1016/j.neuropharm.2024.110101
Publication status	Published - 1 Dec 2024

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title = "Medial prefrontal cortex circuitry and social behaviour in autism",

abstract = "Autism spectrum disorder (ASD) has proven to be highly enigmatic due to the diversity of its underlying genetic causes and the huge variability in symptom presentation. Uncovering common phenotypes across people with ASD and pre-clinical models allows us to better understand the influence on brain function of the many different genetic and cellular processes thought to contribute to ASD aetiology. One such feature of ASD is the convergent evidence implicating abnormal functioning of the medial prefrontal cortex (mPFC) across studies. The mPFC is a key part of the 'social brain' and may contribute to many of the changes in social behaviour observed in people with ASD. Here we review recent evidence for mPFC involvement in both ASD and social behaviours. We also highlight how pre-clinical mouse models can be used to uncover important cellular and circuit-level mechanisms that may underly atypical social behaviours in ASD.This article is part of the Special Issue on {"}PFC circuit function in psychiatric disease and relevant models{"}.",

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AU - Mediane, Diego H.

AU - Basu, Shinjini

AU - Cahill, Emma N.

AU - Anastasiades, Paul G.

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N2 - Autism spectrum disorder (ASD) has proven to be highly enigmatic due to the diversity of its underlying genetic causes and the huge variability in symptom presentation. Uncovering common phenotypes across people with ASD and pre-clinical models allows us to better understand the influence on brain function of the many different genetic and cellular processes thought to contribute to ASD aetiology. One such feature of ASD is the convergent evidence implicating abnormal functioning of the medial prefrontal cortex (mPFC) across studies. The mPFC is a key part of the 'social brain' and may contribute to many of the changes in social behaviour observed in people with ASD. Here we review recent evidence for mPFC involvement in both ASD and social behaviours. We also highlight how pre-clinical mouse models can be used to uncover important cellular and circuit-level mechanisms that may underly atypical social behaviours in ASD.This article is part of the Special Issue on "PFC circuit function in psychiatric disease and relevant models".

AB - Autism spectrum disorder (ASD) has proven to be highly enigmatic due to the diversity of its underlying genetic causes and the huge variability in symptom presentation. Uncovering common phenotypes across people with ASD and pre-clinical models allows us to better understand the influence on brain function of the many different genetic and cellular processes thought to contribute to ASD aetiology. One such feature of ASD is the convergent evidence implicating abnormal functioning of the medial prefrontal cortex (mPFC) across studies. The mPFC is a key part of the 'social brain' and may contribute to many of the changes in social behaviour observed in people with ASD. Here we review recent evidence for mPFC involvement in both ASD and social behaviours. We also highlight how pre-clinical mouse models can be used to uncover important cellular and circuit-level mechanisms that may underly atypical social behaviours in ASD.This article is part of the Special Issue on "PFC circuit function in psychiatric disease and relevant models".

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DO - 10.1016/j.neuropharm.2024.110101

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Medial prefrontal cortex circuitry and social behaviour in autism

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