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Medicines in pregnancy

Research output: Contribution to journalReview article

  • Sarah Stock
  • Jane Norman
Original languageEnglish
Pages (from-to)1-13
Number of pages13
JournalF1000Research
Volume8
Issue number911
DOIs
DateAccepted/In press - 12 Jun 2019
DatePublished (current) - 20 Jun 2019

Abstract

Medicine use in pregnancy is extremely common, but there are significant knowledge gaps surrounding the safety, dosage and long-term effects of drugs used. Pregnant women have been purposively excluded from clinical trials of the majority of treatments for conditions that may occur concurrently with pregnancy. There is minimal information on the pharmacokinetics of many existing treatments, and no systematic capture of long-term outcome data to help inform choices. Treatments commonly used in pregnancy are thus often old and untested, not optimised in dose, and prescribed off-label without adequate safety information. In addition, there has been a staggering lack of investment in drug development for obstetric conditions for decades. This is a major public health concern, with pregnancy complications the leading cause of mortality in children under five years old globally, and health in pregnancy a major determinant of women’s long-term health and wellbeing. There is an acute need for adequate investment and legislation to boost inclusion of pregnant women in clinical studies, capture high-quality information on medication use in pregnancy in general, and encourage new medicinal product development for obstetric conditions.

    Research areas

  • Pregnancy, Pharmacokinetics, Pharmacovigilance, MEDICINES, Public health, Maternal Health, newborn health, child health

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    Rights statement: This is the final published version of the article (version of record). It first appeared online via F1000 Research at https://doi.org/10.12688/f1000research.17535.1 . Please refer to any applicable terms of use of the publisher.

    Final published version, 641 KB, PDF document

    Licence: CC BY

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