Mediterranean diet and risk of heart failure: Results from the PREDIMED randomized controlled trial

Angeliki Papadaki; Miguel Ángel Martínez-González; Angel Alonso-Gómez; Javier Rekondo; Jordi Salas-Salvadó; Dolores Corella; Emilio Ros; Montse Fitó; Ramon Estruch; José Lapetra; Antonio García-Rodriguez; Miquel Fiol; Lluís Serra-Majem; Xavier Pintó; Miguel Ruiz-Canela; Monica Bulló; Mercè Serra-Mir; Jose V. Sorlí; Fernando Arós

doi:10.1002/ejhf.750

Mediterranean diet and risk of heart failure: Results from the PREDIMED randomized controlled trial

Angeliki Papadaki, Miguel Ángel Martínez-González, Angel Alonso-Gómez, Javier Rekondo, Jordi Salas-Salvadó, Dolores Corella, Emilio Ros, Montse Fitó, Ramon Estruch, José Lapetra, Antonio García-Rodriguez, Miquel Fiol, Lluís Serra-Majem, Xavier Pintó, Miguel Ruiz-Canela, Monica Bulló, Mercè Serra-Mir, Jose V. Sorlí, Fernando Arós^*

^*Corresponding author for this work

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Abstract

Aims: The aim of this study was to evaluate the effect of the Mediterranean diet (MedDiet) on the incidence of heart failure (HF), a pre-specified secondary outcome in the PREDIMED (PREvención con DIeta MEDiterránea) primary nutrition-intervention prevention trial. Methods and results: Participants at high risk of cardiovascular disease were randomly assigned to one of three diets: MedDiet supplemented with extra-virgin olive oil (EVOO), MedDiet supplemented with nuts, or a low-fat control diet. Incident HF was ascertained by a Committee for Adjudication of events blinded to group allocation. Among 7403 participants without prevalent HF followed for a median of 4.8 years, we observed 29 new HF cases in the MedDiet with EVOO group, 33 in the MedDiet with nuts group, and 32 in the control group. No significant association with HF incidence was found for the MedDiet with EVOO and MedDiet with nuts, compared with the control group [hazard ratio (HR) 0.68; 95% confidence interval (CI) 0.41-1.13, and HR 0.92; 95% CI 0.56-1.49, respectively]. Conclusion: In this sample of adults at high cardiovascular risk, the MedDiet did not result in lower HF incidence. However, this pre-specified secondary analysis may have been underpowered to provide valid conclusions. Further randomized controlled trials with HF as a primary outcome are needed to better assess the effect of the MedDiet on HF risk. Trial registration: ISRCTN35739639.

Original language	English
Pages (from-to)	1179-1185
Number of pages	7
Journal	European Journal of Heart Failure
Volume	19
Issue number	9
Early online date	30 Jan 2017
DOIs	https://doi.org/10.1002/ejhf.750
Publication status	Published - Sept 2017

Bibliographical note

Acceptance email received 13/12/2016

Keywords

AF, atrial fibrillation
BMI, body mass index
CHD, coronary heart disease
CVD, cardiovascular disease
EVOO, extra virgin olive oil
FFQ, food frequency questionnaire
HDL, high-density lipoprotein
HF, heart failure
LDL, low-density lipoprotein
MedDiet, Mediterranean diet
MI, myocardial infarction
PAD, peripheral arterial disease
PREDIMED, Prevención con Dieta Mediterránea
T2D, type 2 diabetes
WtHR, waist-to-height ratio

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/ejhf.750

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Papadaki, A., Martínez-González, M. Á., Alonso-Gómez, A., Rekondo, J., Salas-Salvadó, J., Corella, D., Ros, E., Fitó, M., Estruch, R., Lapetra, J., García-Rodriguez, A., Fiol, M., Serra-Majem, L., Pintó, X., Ruiz-Canela, M., Bulló, M., Serra-Mir, M., Sorlí, J. V., & Arós, F. (2017). Mediterranean diet and risk of heart failure: Results from the PREDIMED randomized controlled trial. European Journal of Heart Failure, 19(9), 1179-1185. https://doi.org/10.1002/ejhf.750

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title = "Mediterranean diet and risk of heart failure: Results from the PREDIMED randomized controlled trial",

abstract = "Aims: The aim of this study was to evaluate the effect of the Mediterranean diet (MedDiet) on the incidence of heart failure (HF), a pre-specified secondary outcome in the PREDIMED (PREvenci{\'o}n con DIeta MEDiterr{\'a}nea) primary nutrition-intervention prevention trial. Methods and results: Participants at high risk of cardiovascular disease were randomly assigned to one of three diets: MedDiet supplemented with extra-virgin olive oil (EVOO), MedDiet supplemented with nuts, or a low-fat control diet. Incident HF was ascertained by a Committee for Adjudication of events blinded to group allocation. Among 7403 participants without prevalent HF followed for a median of 4.8 years, we observed 29 new HF cases in the MedDiet with EVOO group, 33 in the MedDiet with nuts group, and 32 in the control group. No significant association with HF incidence was found for the MedDiet with EVOO and MedDiet with nuts, compared with the control group [hazard ratio (HR) 0.68; 95% confidence interval (CI) 0.41-1.13, and HR 0.92; 95% CI 0.56-1.49, respectively]. Conclusion: In this sample of adults at high cardiovascular risk, the MedDiet did not result in lower HF incidence. However, this pre-specified secondary analysis may have been underpowered to provide valid conclusions. Further randomized controlled trials with HF as a primary outcome are needed to better assess the effect of the MedDiet on HF risk. Trial registration: ISRCTN35739639.",

keywords = "AF, atrial fibrillation, BMI, body mass index, CHD, coronary heart disease, CVD, cardiovascular disease, EVOO, extra virgin olive oil, FFQ, food frequency questionnaire, HDL, high-density lipoprotein, HF, heart failure, LDL, low-density lipoprotein, MedDiet, Mediterranean diet, MI, myocardial infarction, PAD, peripheral arterial disease, PREDIMED, Prevenci{\'o}n con Dieta Mediterr{\'a}nea, T2D, type 2 diabetes, WtHR, waist-to-height ratio",

author = "Angeliki Papadaki and Mart{\'i}nez-Gonz{\'a}lez, {Miguel {\'A}ngel} and Angel Alonso-G{\'o}mez and Javier Rekondo and Jordi Salas-Salvad{\'o} and Dolores Corella and Emilio Ros and Montse Fit{\'o} and Ramon Estruch and Jos{\'e} Lapetra and Antonio Garc{\'i}a-Rodriguez and Miquel Fiol and Llu{\'i}s Serra-Majem and Xavier Pint{\'o} and Miguel Ruiz-Canela and Monica Bull{\'o} and Merc{\`e} Serra-Mir and Sorl{\'i}, {Jose V.} and Fernando Ar{\'o}s",

note = "Acceptance email received 13/12/2016",

year = "2017",

month = sep,

doi = "10.1002/ejhf.750",

language = "English",

volume = "19",

pages = "1179--1185",

journal = "European Journal of Heart Failure",

issn = "1388-9842",

publisher = "Wiley",

number = "9",

}

Papadaki, A, Martínez-González, MÁ, Alonso-Gómez, A, Rekondo, J, Salas-Salvadó, J, Corella, D, Ros, E, Fitó, M, Estruch, R, Lapetra, J, García-Rodriguez, A, Fiol, M, Serra-Majem, L, Pintó, X, Ruiz-Canela, M, Bulló, M, Serra-Mir, M, Sorlí, JV & Arós, F 2017, 'Mediterranean diet and risk of heart failure: Results from the PREDIMED randomized controlled trial', European Journal of Heart Failure, vol. 19, no. 9, pp. 1179-1185. https://doi.org/10.1002/ejhf.750

TY - JOUR

T1 - Mediterranean diet and risk of heart failure

T2 - Results from the PREDIMED randomized controlled trial

AU - Papadaki, Angeliki

AU - Martínez-González, Miguel Ángel

AU - Alonso-Gómez, Angel

AU - Rekondo, Javier

AU - Salas-Salvadó, Jordi

AU - Corella, Dolores

AU - Ros, Emilio

AU - Fitó, Montse

AU - Estruch, Ramon

AU - Lapetra, José

AU - García-Rodriguez, Antonio

AU - Fiol, Miquel

AU - Serra-Majem, Lluís

AU - Pintó, Xavier

AU - Ruiz-Canela, Miguel

AU - Bulló, Monica

AU - Serra-Mir, Mercè

AU - Sorlí, Jose V.

AU - Arós, Fernando

N1 - Acceptance email received 13/12/2016

PY - 2017/9

Y1 - 2017/9

N2 - Aims: The aim of this study was to evaluate the effect of the Mediterranean diet (MedDiet) on the incidence of heart failure (HF), a pre-specified secondary outcome in the PREDIMED (PREvención con DIeta MEDiterránea) primary nutrition-intervention prevention trial. Methods and results: Participants at high risk of cardiovascular disease were randomly assigned to one of three diets: MedDiet supplemented with extra-virgin olive oil (EVOO), MedDiet supplemented with nuts, or a low-fat control diet. Incident HF was ascertained by a Committee for Adjudication of events blinded to group allocation. Among 7403 participants without prevalent HF followed for a median of 4.8 years, we observed 29 new HF cases in the MedDiet with EVOO group, 33 in the MedDiet with nuts group, and 32 in the control group. No significant association with HF incidence was found for the MedDiet with EVOO and MedDiet with nuts, compared with the control group [hazard ratio (HR) 0.68; 95% confidence interval (CI) 0.41-1.13, and HR 0.92; 95% CI 0.56-1.49, respectively]. Conclusion: In this sample of adults at high cardiovascular risk, the MedDiet did not result in lower HF incidence. However, this pre-specified secondary analysis may have been underpowered to provide valid conclusions. Further randomized controlled trials with HF as a primary outcome are needed to better assess the effect of the MedDiet on HF risk. Trial registration: ISRCTN35739639.

AB - Aims: The aim of this study was to evaluate the effect of the Mediterranean diet (MedDiet) on the incidence of heart failure (HF), a pre-specified secondary outcome in the PREDIMED (PREvención con DIeta MEDiterránea) primary nutrition-intervention prevention trial. Methods and results: Participants at high risk of cardiovascular disease were randomly assigned to one of three diets: MedDiet supplemented with extra-virgin olive oil (EVOO), MedDiet supplemented with nuts, or a low-fat control diet. Incident HF was ascertained by a Committee for Adjudication of events blinded to group allocation. Among 7403 participants without prevalent HF followed for a median of 4.8 years, we observed 29 new HF cases in the MedDiet with EVOO group, 33 in the MedDiet with nuts group, and 32 in the control group. No significant association with HF incidence was found for the MedDiet with EVOO and MedDiet with nuts, compared with the control group [hazard ratio (HR) 0.68; 95% confidence interval (CI) 0.41-1.13, and HR 0.92; 95% CI 0.56-1.49, respectively]. Conclusion: In this sample of adults at high cardiovascular risk, the MedDiet did not result in lower HF incidence. However, this pre-specified secondary analysis may have been underpowered to provide valid conclusions. Further randomized controlled trials with HF as a primary outcome are needed to better assess the effect of the MedDiet on HF risk. Trial registration: ISRCTN35739639.

KW - AF, atrial fibrillation

KW - BMI, body mass index

KW - CHD, coronary heart disease

KW - CVD, cardiovascular disease

KW - EVOO, extra virgin olive oil

KW - FFQ, food frequency questionnaire

KW - HDL, high-density lipoprotein

KW - HF, heart failure

KW - LDL, low-density lipoprotein

KW - MedDiet, Mediterranean diet

KW - MI, myocardial infarction

KW - PAD, peripheral arterial disease

KW - PREDIMED, Prevención con Dieta Mediterránea

KW - T2D, type 2 diabetes

KW - WtHR, waist-to-height ratio

UR - http://www.scopus.com/inward/record.url?scp=85011072028&partnerID=8YFLogxK

U2 - 10.1002/ejhf.750

DO - 10.1002/ejhf.750

M3 - Article (Academic Journal)

C2 - 28133855

AN - SCOPUS:85011072028

SN - 1388-9842

VL - 19

SP - 1179

EP - 1185

JO - European Journal of Heart Failure

JF - European Journal of Heart Failure

IS - 9

ER -

Mediterranean diet and risk of heart failure: Results from the PREDIMED randomized controlled trial

Abstract

Bibliographical note

Keywords

UN SDGs

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Public University of Navarra

Dr Angeliki Papadaki

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Mediterranean diet and risk of heart failure: Results from the PREDIMED randomized controlled trial

Abstract

Bibliographical note

Keywords

UN SDGs

Access to Document

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Fingerprint

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Public University of Navarra

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Dr Angeliki Papadaki

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