Membrane protein biogenesis by the EMC

Sara Alvira, Robin A Corey, Ian R Collinson, Karin Römisch*

*Corresponding author for this work

Research output: Contribution to journalArticle (Academic Journal)peer-review

5 Citations (Scopus)
80 Downloads (Pure)


The endoplasmic reticulum (ER) membrane protein complex (EMC) was identified over a decade ago in a genetic screen for ER protein homeostasis. The EMC inserts transmembrane domains (TMDs) with limited hydrophobicity. Two recent cryo‐EM structures, and a third model based on partial high‐ and low‐resolution structures, suggest how this is accomplished.
Original languageEnglish
Article numbere107407
Number of pages3
JournalEMBO Journal
Issue number2
Publication statusPublished - 21 Dec 2020


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