Membrane protein biogenesis by the EMC

Sara  Alvira; Robin A Corey; Ian R Collinson; Karin Römisch

doi:10.15252/embj.2020107407

Membrane protein biogenesis by the EMC

Sara Alvira, Robin A Corey, Ian R Collinson, Karin Römisch^*

^*Corresponding author for this work

Research output: Contribution to journal › Article (Academic Journal) › peer-review

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Abstract

The endoplasmic reticulum (ER) membrane protein complex (EMC) was identified over a decade ago in a genetic screen for ER protein homeostasis. The EMC inserts transmembrane domains (TMDs) with limited hydrophobicity. Two recent cryo‐EM structures, and a third model based on partial high‐ and low‐resolution structures, suggest how this is accomplished.

Original language	English
Article number	e107407
Number of pages	3
Journal	EMBO Journal
Volume	40
Issue number	2
DOIs	https://doi.org/10.15252/embj.2020107407
Publication status	Published - 21 Dec 2020

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title = "Membrane protein biogenesis by the EMC",

abstract = "The endoplasmic reticulum (ER) membrane protein complex (EMC) was identified over a decade ago in a genetic screen for ER protein homeostasis. The EMC inserts transmembrane domains (TMDs) with limited hydrophobicity. Two recent cryo‐EM structures, and a third model based on partial high‐ and low‐resolution structures, suggest how this is accomplished.",

author = "Sara Alvira and Corey, {Robin A} and Collinson, {Ian R} and Karin R{\"o}misch",

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AU - Alvira, Sara

AU - Corey, Robin A

AU - Collinson, Ian R

AU - Römisch, Karin

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N2 - The endoplasmic reticulum (ER) membrane protein complex (EMC) was identified over a decade ago in a genetic screen for ER protein homeostasis. The EMC inserts transmembrane domains (TMDs) with limited hydrophobicity. Two recent cryo‐EM structures, and a third model based on partial high‐ and low‐resolution structures, suggest how this is accomplished.

AB - The endoplasmic reticulum (ER) membrane protein complex (EMC) was identified over a decade ago in a genetic screen for ER protein homeostasis. The EMC inserts transmembrane domains (TMDs) with limited hydrophobicity. Two recent cryo‐EM structures, and a third model based on partial high‐ and low‐resolution structures, suggest how this is accomplished.

U2 - 10.15252/embj.2020107407

DO - 10.15252/embj.2020107407

M3 - Article (Academic Journal)

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SN - 0261-4189

VL - 40

JO - EMBO Journal

JF - EMBO Journal

IS - 2

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ER -

Membrane protein biogenesis by the EMC

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