Memory trace replay: The shaping of memory consolidation by neuromodulation

Laura A Atherton, David Duprett, Jack R Mellor

Research output: Contribution to journalArticle (Academic Journal)peer-review

73 Citations (Scopus)
468 Downloads (Pure)


The consolidation of memories for places and events is thought to rely, at the network level, on the replay of spatially tuned neuronal firing patterns representing discrete places and spatial trajectories. This occurs in the hippocampal-entorhinal circuit during sharp wave ripple events (SWRs) that occur during sleep or rest. Here, we review theoretical models of lingering place cell excitability and behaviorally induced synaptic plasticity within cell assemblies to explain which sequences or places are replayed. We further provide new insights into how fluctuations in cholinergic tone during different behavioral states might shape the direction of replay and how dopaminergic release in response to novelty or reward can modulate which cell assemblies are replayed.
Original languageEnglish
Pages (from-to)560-570
Number of pages11
JournalTrends in Neurosciences
Issue number9
Early online date11 Aug 2015
Publication statusPublished - 1 Sep 2015


  • hippocampus
  • sharp-wave ripples
  • replay
  • synaptic plasticity
  • dopamine
  • acetylcholine

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