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Mendelian randomization: A novel approach for the prediction of adverse drug events and drug repurposing opportunities

Research output: Contribution to journalArticle

Original languageEnglish
Pages (from-to)2078-2089
Number of pages12
JournalInternational Journal of Epidemiology
Volume46
Issue number6
Early online date11 Oct 2017
DOIs
DateAccepted/In press - 5 Sep 2017
DateE-pub ahead of print - 11 Oct 2017
DatePublished (current) - 1 Dec 2017

Abstract

Identification of unintended drug effects, specifically drug repurposing opportunities and adverse drug events, maximizes the benefit of a drug and protects the health of patients. However, current observational research methods are subject to several biases. These include confounding by indication, reverse causality and missing data. We propose that Mendelian randomization (MR) offers a novel approach for the prediction of unintended drug effects. In particular, we advocate the synthesis of evidence from this method and other approaches, in the spirit of triangulation, to improve causal inferences concerning drug effects. MR addresses some of the limitations associated with the existing methods in this field. Furthermore, it can be applied either before or after approval of the drug, and could therefore prevent the potentially harmful exposure of patients in clinical trials and beyond. The potential of MR as a pharmacovigilance and drug repurposing tool is yet to be realized, and could both help prevent adverse drug events and identify novel indications for existing drugs in the future.

    Research areas

  • Adverse drug events, Drug repurposing, Mendelian randomization, Pharmacovigilance

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    Rights statement: This is the final published version of the article (version of record). It first appeared online via Oxford University Press at https://academic.oup.com/ije/article/doi/10.1093/ije/dyx207/4430993/Mendelian-randomization-a-novel-approach-for-the. Please refer to any applicable terms of use of the publisher.

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