Projects per year
Identification of unintended drug effects, specifically drug repurposing opportunities and adverse drug events, maximizes the benefit of a drug and protects the health of patients. However, current observational research methods are subject to several biases. These include confounding by indication, reverse causality and missing data. We propose that Mendelian randomization (MR) offers a novel approach for the prediction of unintended drug effects. In particular, we advocate the synthesis of evidence from this method and other approaches, in the spirit of triangulation, to improve causal inferences concerning drug effects. MR addresses some of the limitations associated with the existing methods in this field. Furthermore, it can be applied either before or after approval of the drug, and could therefore prevent the potentially harmful exposure of patients in clinical trials and beyond. The potential of MR as a pharmacovigilance and drug repurposing tool is yet to be realized, and could both help prevent adverse drug events and identify novel indications for existing drugs in the future.
|Number of pages||12|
|Journal||International Journal of Epidemiology|
|Early online date||11 Oct 2017|
|Publication status||Published - 1 Dec 2017|
- Adverse drug events
- Drug repurposing
- Mendelian randomization
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- 2 Finished
MRC UoB UNITE Unit - Programme 1
1/06/13 → 31/03/18
IEU Theme 3
Windmeijer, F., Tilling, K. M. & Tilling, K. M.
1/06/13 → 31/03/18
New uses for old drugs : Investigating whether antihypertensives can be repurposed for the prevention of dementiaAuthor: Walker, V., 13 Sept 2019
Supervisor: Davies, N. (Supervisor), Kehoe, P. (Supervisor) & Martin, R. (Supervisor)
Student thesis: Doctoral Thesis › Doctor of Philosophy (PhD)File
Professor Richard M Martin
- Bristol Medical School (PHS) - Professor of Clinical Epidemiology & Deputy Head of Bristol Medical School & Head of PHS
- Bristol Population Health Science Institute
- MRC Integrative Epidemiology Unit
Person: Academic , Member