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Mendelian Randomization for Nutritional Psychiatry

Research output: Contribution to journalArticle

Original languageEnglish
Number of pages9
JournalLancet Psychiatry
DOIs
DateSubmitted - 30 May 2019
DateAccepted/In press - 12 Jul 2019
DatePublished (current) - 20 Nov 2019

Abstract

Nutritional psychiatry is a growing area of research, with several nutritional factors implicated in the aetiology of psychiatric ill health. However, nutritional research is highly complex, with multiple potential factors involved, highly confounded exposures and small individual effect sizes. This paper considers whether Mendelian randomization provides a solution to these difficulties, by investigating causality in a low risk and low-cost way. Current studies using MR in nutritional psychiatry are reviewed, along with the potential opportunities and challenges of using this approach for investigating the causal effects of nutritional exposures. Several studies have identified potentially causal nutritional exposures using Mendelian randomisation in psychiatry, offering opportunities for further mechanistic research, intervention development, and replication. Using Mendelian randomisation as a foundation for intervention development allows the best use of resources in an emerging discipline in which opportunities are rich, but resources are often poor.

    Research areas

  • Mendelian randomization, nutritional psychiatry, causality

    Structured keywords

  • Brain and Behaviour
  • Tobacco and Alcohol

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Documents

  • Full-text PDF (accepted author manuscript)

    Rights statement: This is the author accepted manuscript (AAM). The final published version (version of record) is available online via Elsevier at https://www.thelancet.com/journals/lanpsy/article/PIIS2215-0366(19)30293-7/fulltext . Please refer to any applicable terms of use of the publisher.

    Accepted author manuscript, 834 KB, PDF document

    Embargo ends: 20/05/20

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    Licence: CC BY-NC-ND

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