Meningococcal interactions with the host

Etienne Carbonnelle, Darryl J. Hill, Philippe Morand, Natalie J. Griffiths, Sandrine Bourdoulous, Isabel Murillo Cabeza, Xavier Nassif, Mumtaz Virji*

*Corresponding author for this work

Research output: Contribution to journalArticle (Academic Journal)peer-review

73 Citations (Scopus)

Abstract

Neisseria meningitidis interacts with host tissues through hierarchical, concerted and co-ordinated actions of a number of adhesins: many of which undergo antigenic and phase variation, a strategy that helps immune evasion. Three major structures, pili, Opa and Opc predominantly influence bacterial adhesion to host cells. Pili and Opa proteins also determine host and tissue specificity while Opa and Opc facilitate efficient cellular invasion. Recent studies have also implied a role of certain adhesin-receptor pairs in determining increased host susceptibility to infection. This chapter examines our current knowledge of meningococcal adhesion and invasion mechanisms particularly related to human epithelial and endothelial cells which are of primary importance in the disease process. (C) 2009 Elsevier Ltd. All rights reserved.

Translated title of the contributionMeningococcal interactions with the host
Original languageEnglish
Pages (from-to)B78-B89
Number of pages12
JournalVaccine
Volume27
Issue number2
DOIs
Publication statusPublished - 24 Jun 2009

Bibliographical note

Publisher: Elsevier

Keywords

  • Adhesion
  • Receptors
  • Pathogenic mechanisms
  • OUTER-MEMBRANE PROTEIN
  • HUMAN ENDOTHELIAL-CELLS
  • IV PILUS BIOGENESIS
  • IMMUNOGENIC AUTOTRANSPORTER PROTEIN
  • TRANSMISSION ELECTRON-MICROSCOPY
  • 2-PARTNER SECRETION SYSTEM
  • MENINGITIDIS SEROGROUP-B
  • HUMAN EPITHELIAL-CELLS
  • BLOOD-BRAIN-BARRIER
  • NEISSERIA-MENINGITIDIS

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