Meningococcal interactions with the host

Etienne Carbonnelle; Darryl J. Hill; Philippe Morand; Natalie J. Griffiths; Sandrine Bourdoulous; Isabel Murillo Cabeza; Xavier Nassif; Mumtaz Virji

doi:10.1016/j.vaccine.2009.04.069

Meningococcal interactions with the host

Etienne Carbonnelle
, Darryl J. Hill
, Philippe Morand
, Natalie J. Griffiths
, Sandrine Bourdoulous
, Isabel Murillo Cabeza
, Xavier Nassif
, Mumtaz Virji^*

^*Corresponding author for this work

Research output: Contribution to journal › Article (Academic Journal) › peer-review

89 Citations (Scopus)

Abstract

Neisseria meningitidis interacts with host tissues through hierarchical, concerted and co-ordinated actions of a number of adhesins: many of which undergo antigenic and phase variation, a strategy that helps immune evasion. Three major structures, pili, Opa and Opc predominantly influence bacterial adhesion to host cells. Pili and Opa proteins also determine host and tissue specificity while Opa and Opc facilitate efficient cellular invasion. Recent studies have also implied a role of certain adhesin-receptor pairs in determining increased host susceptibility to infection. This chapter examines our current knowledge of meningococcal adhesion and invasion mechanisms particularly related to human epithelial and endothelial cells which are of primary importance in the disease process. (C) 2009 Elsevier Ltd. All rights reserved.

Original language	English
Pages (from-to)	B78-B89
Number of pages	12
Journal	Vaccine
Volume	27
Issue number	2
DOIs	https://doi.org/10.1016/j.vaccine.2009.04.069
Publication status	Published - 24 Jun 2009

Bibliographical note

Publisher: Elsevier

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Adhesion
Receptors
Pathogenic mechanisms
OUTER-MEMBRANE PROTEIN
HUMAN ENDOTHELIAL-CELLS
IV PILUS BIOGENESIS
IMMUNOGENIC AUTOTRANSPORTER PROTEIN
TRANSMISSION ELECTRON-MICROSCOPY
2-PARTNER SECRETION SYSTEM
MENINGITIDIS SEROGROUP-B
HUMAN EPITHELIAL-CELLS
BLOOD-BRAIN-BARRIER
NEISSERIA-MENINGITIDIS

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10.1016/j.vaccine.2009.04.069

http://www.sciencedirect.com/science/article/pii/S0264410X09006367

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Cite this

@article{f5d9aa89c0804cd59eefadfeb9b79524,

title = "Meningococcal interactions with the host",

abstract = "Neisseria meningitidis interacts with host tissues through hierarchical, concerted and co-ordinated actions of a number of adhesins: many of which undergo antigenic and phase variation, a strategy that helps immune evasion. Three major structures, pili, Opa and Opc predominantly influence bacterial adhesion to host cells. Pili and Opa proteins also determine host and tissue specificity while Opa and Opc facilitate efficient cellular invasion. Recent studies have also implied a role of certain adhesin-receptor pairs in determining increased host susceptibility to infection. This chapter examines our current knowledge of meningococcal adhesion and invasion mechanisms particularly related to human epithelial and endothelial cells which are of primary importance in the disease process. (C) 2009 Elsevier Ltd. All rights reserved.",

keywords = "Adhesion, Receptors, Pathogenic mechanisms, OUTER-MEMBRANE PROTEIN, HUMAN ENDOTHELIAL-CELLS, IV PILUS BIOGENESIS, IMMUNOGENIC AUTOTRANSPORTER PROTEIN, TRANSMISSION ELECTRON-MICROSCOPY, 2-PARTNER SECRETION SYSTEM, MENINGITIDIS SEROGROUP-B, HUMAN EPITHELIAL-CELLS, BLOOD-BRAIN-BARRIER, NEISSERIA-MENINGITIDIS",

author = "Etienne Carbonnelle and Hill, \{Darryl J.\} and Philippe Morand and Griffiths, \{Natalie J.\} and Sandrine Bourdoulous and \{Murillo Cabeza\}, Isabel and Xavier Nassif and Mumtaz Virji",

note = "Publisher: Elsevier",

year = "2009",

month = jun,

day = "24",

doi = "10.1016/j.vaccine.2009.04.069",

language = "English",

volume = "27",

pages = "B78--B89",

journal = "Vaccine",

issn = "0264-410X",

publisher = "Elsevier Limited",

number = "2",

}

TY - JOUR

T1 - Meningococcal interactions with the host

AU - Carbonnelle, Etienne

AU - Hill, Darryl J.

AU - Morand, Philippe

AU - Griffiths, Natalie J.

AU - Bourdoulous, Sandrine

AU - Murillo Cabeza, Isabel

AU - Nassif, Xavier

AU - Virji, Mumtaz

N1 - Publisher: Elsevier

PY - 2009/6/24

Y1 - 2009/6/24

N2 - Neisseria meningitidis interacts with host tissues through hierarchical, concerted and co-ordinated actions of a number of adhesins: many of which undergo antigenic and phase variation, a strategy that helps immune evasion. Three major structures, pili, Opa and Opc predominantly influence bacterial adhesion to host cells. Pili and Opa proteins also determine host and tissue specificity while Opa and Opc facilitate efficient cellular invasion. Recent studies have also implied a role of certain adhesin-receptor pairs in determining increased host susceptibility to infection. This chapter examines our current knowledge of meningococcal adhesion and invasion mechanisms particularly related to human epithelial and endothelial cells which are of primary importance in the disease process. (C) 2009 Elsevier Ltd. All rights reserved.

AB - Neisseria meningitidis interacts with host tissues through hierarchical, concerted and co-ordinated actions of a number of adhesins: many of which undergo antigenic and phase variation, a strategy that helps immune evasion. Three major structures, pili, Opa and Opc predominantly influence bacterial adhesion to host cells. Pili and Opa proteins also determine host and tissue specificity while Opa and Opc facilitate efficient cellular invasion. Recent studies have also implied a role of certain adhesin-receptor pairs in determining increased host susceptibility to infection. This chapter examines our current knowledge of meningococcal adhesion and invasion mechanisms particularly related to human epithelial and endothelial cells which are of primary importance in the disease process. (C) 2009 Elsevier Ltd. All rights reserved.

KW - Adhesion

KW - Receptors

KW - Pathogenic mechanisms

KW - OUTER-MEMBRANE PROTEIN

KW - HUMAN ENDOTHELIAL-CELLS

KW - IV PILUS BIOGENESIS

KW - IMMUNOGENIC AUTOTRANSPORTER PROTEIN

KW - TRANSMISSION ELECTRON-MICROSCOPY

KW - 2-PARTNER SECRETION SYSTEM

KW - MENINGITIDIS SEROGROUP-B

KW - HUMAN EPITHELIAL-CELLS

KW - BLOOD-BRAIN-BARRIER

KW - NEISSERIA-MENINGITIDIS

UR - https://www.scopus.com/pages/publications/67349101201

U2 - 10.1016/j.vaccine.2009.04.069

DO - 10.1016/j.vaccine.2009.04.069

M3 - Article (Academic Journal)

C2 - 19481311

SN - 0264-410X

VL - 27

SP - B78-B89

JO - Vaccine

JF - Vaccine

IS - 2

ER -

Meningococcal interactions with the host

Abstract

Bibliographical note

UN SDGs

Keywords

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DEVELOPMENT OF IN VITRO MODEL TO STUDY BACTERIAL INTERACTIONS WITH LYMPHOID TISSUE ASSOCIATED EPITHELIAL CELLS

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Meningococcal interactions with the host

Abstract

Bibliographical note

UN SDGs

Keywords

Access to Document

Handle.net

Other files and links

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DEVELOPMENT OF IN VITRO MODEL TO STUDY BACTERIAL INTERACTIONS WITH LYMPHOID TISSUE ASSOCIATED EPITHELIAL CELLS

Cite this