Meningococcal vaccines and herd immunity -lessons learnt from serogroup C conjugate vaccination programmes

CL Trotter, MCJ Maiden

Research output: Contribution to journalArticle (Academic Journal)peer-review

Abstract

Effective vaccines provide direct protection to immunized individuals, but may also provide benefits to unvaccinated individuals by reducing transmission and thereby lowering the risk of infection. Such herd immunity effects have been demonstrated following the introduction of meningococcal serogroup C conjugate (MCC) vaccines, with reductions in disease attack rates in unimmunized individuals and significantly lower serogroup C carriage attributable to the vaccine introduction. In the UK, targeting teenagers for immunization was crucial in maximizing indirect effects, as most meningococcal transmission occurs in this age group. Questions remain regarding the duration of herd protection and the most appropriate long-term immunization strategies. The magnitude of the herd effects following MCC vaccination was largely unanticipated, and has important consequences for the design and evaluation of new meningococcal vaccines.
Translated title of the contributionMeningococcal vaccines and herd immunity -lessons learnt from serogroup C conjugate vaccination programmes
Original languageEnglish
Pages (from-to)851 - 861
JournalExpert Review of Vaccines
Volume8
Publication statusPublished - Jul 2009

Fingerprint Dive into the research topics of 'Meningococcal vaccines and herd immunity -lessons learnt from serogroup C conjugate vaccination programmes'. Together they form a unique fingerprint.

Cite this