MEPE loss-of-function variant associates with decreased bone mineral density and increased fracture risk

Regeneron Genetics Center

Research output: Contribution to journalArticle (Academic Journal)peer-review

Abstract

A major challenge in genetic association studies is that most associated variants fall in the non-coding part of the human genome. We searched for variants associated with bone mineral density (BMD) after enriching the discovery cohort for loss-of-function (LoF) mutations by sequencing a subset of the Nord-Trøndelag Health Study, followed by imputation in the remaining sample (N = 19,705), and identified ten known BMD loci. However, one previously unreported variant, LoF mutation in MEPE, p.(Lys70IlefsTer26, minor allele frequency [MAF] = 0.8%), was associated with decreased ultradistal forearm BMD (P-value = 2.1 × 10-18), and increased osteoporosis (P-value = 4.2 × 10-5) and fracture risk (P-value = 1.6 × 10-5). The MEPE LoF association with BMD and fractures was further evaluated in 279,435 UK (MAF = 0.05%, heel bone estimated BMD P-value = 1.2 × 10-16, any fracture P-value = 0.05) and 375,984 Icelandic samples (MAF = 0.03%, arm BMD P-value = 0.12, forearm fracture P-value = 0.005). Screening for the MEPE LoF mutations before adulthood could potentially prevent osteoporosis and fractures due to the lifelong effect on BMD observed in the study. A key implication for precision medicine is that high-impact functional variants missing from the publicly available cosmopolitan panels could be clinically more relevant than polygenic risk scores.

Original languageEnglish
Pages (from-to)4093
JournalNature Communications
Volume11
Issue number1
DOIs
Publication statusPublished - 23 Oct 2020

Keywords

  • Adult
  • Aged
  • Aged, 80 and over
  • Bone Density/genetics
  • Cohort Studies
  • Computational Biology
  • Extracellular Matrix Proteins/genetics
  • Female
  • Fractures, Bone/genetics
  • Gene Frequency
  • Genetic Association Studies
  • Genetic Predisposition to Disease/genetics
  • Genetic Testing
  • Genome, Human
  • Glycoproteins/genetics
  • Humans
  • Iceland
  • Male
  • Middle Aged
  • Osteoporosis/genetics
  • Phosphoproteins/genetics

Fingerprint Dive into the research topics of 'MEPE loss-of-function variant associates with decreased bone mineral density and increased fracture risk'. Together they form a unique fingerprint.

Cite this