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Meta-analysis as a system of springs

  • Theodoros Papakonstantinou*
  • , Adriani Nikolakopoulou
  • , Matthias Egger
  • , Georgia Salanti
  • *Corresponding author for this work

Research output: Contribution to journal › Article (Academic Journal) › peer-review

3 Citations (Scopus)

Abstract

Meta-analysis results are usually presented in forest plots, which show the individual study results and the summary effect along with their confidence intervals. In this paper, we propose a system of linear springs as a mechanical analogue of meta-analysis that enables visualization and enhances intuition. The length of a spring corresponds to a study treatment effect and the stiffness of the spring corresponds to its inverse variance. To synthesize study springs we use two main operations: connection in parallel and connection in series. We show the equivalence between meta-analysis and linear springs for fixed effect and random effects pairwise meta-analysis and we also derive indirect treatment effects. We use examples to illustrate the different meta-analytical schemes using the corresponding system of springs. The proposed visualization can serve as an educational tool, especially useful for researchers with no statistical background. The analogy between meta-analysis and springs facilitates intuition for notions such as heterogeneity and the differences between fixed and random effects meta-analysis.

Original languageEnglish
Pages (from-to)20-28
Number of pages9
JournalResearch Synthesis Methods
Volume12
Issue number1
DOIs
Publication statusPublished - 2 Dec 2020

Keywords

  • evidence synthesis
  • mechanical analogue
  • visualization

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