Meta-analysis indicates that common variants at the DISC1 locus are not associated with schizophrenia

I. Mathieson, M. R. Munafo, J. Flint

Research output: Contribution to journalArticle (Academic Journal)peer-review

59 Citations (Scopus)

Abstract

Several polymorphisms in the Disrupted-in-Schizophrenia-1 (DISC1) gene are reported to be associated with schizophrenia. However, to date, there has been little effort to evaluate the evidence for association systematically. We carried out an imputation-driven meta-analysis, the most comprehensive to date, using data collected from 10 candidate gene studies and three genome-wide association studies containing a total of 11 626 cases and 15 237 controls. We tested 1241 single-nucleotide polymorphisms in total, and estimated that our power to detect an effect from a variant with minor allele frequency > 5% was 99% for an odds ratio of 1.5 and 51% for an odds ratio of 1.1. We find no evidence that common variants at the DISC1 locus are associated with schizophrenia. Molecular Psychiatry (2012) 17, 634-641; doi:10.1038/mp.2011.41; published online 12 April 2011

Original languageEnglish
Pages (from-to)634-641
Number of pages8
JournalMolecular Psychiatry
Volume17
Issue number6
DOIs
Publication statusPublished - Jun 2012

Structured keywords

  • Brain and Behaviour
  • Tobacco and Alcohol

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