Projects per year
Abstract
Migraine is a debilitating neurological disorder affecting around one in seven people worldwide, but its molecular mechanisms remain poorly understood. There is some debate about whether migraine is a disease of vascular dysfunction or a result of neuronal dysfunction with secondary vascular changes. Genome-wide association (GWA) studies have thus far identified 13 independent loci associated with migraine. To identify new susceptibility loci, we carried out a genetic study of migraine on 59,674 affected subjects and 316,078 controls from 22 GWA studies. We identified 44 independent single-nucleotide polymorphisms (SNPs) significantly associated with migraine risk (P < 5 × 10(-8)) that mapped to 38 distinct genomic loci, including 28 loci not previously reported and a locus that to our knowledge is the first to be identified on chromosome X. In subsequent computational analyses, the identified loci showed enrichment for genes expressed in vascular and smooth muscle tissues, consistent with a predominant theory of migraine that highlights vascular etiologies.
Original language | English |
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Pages (from-to) | 856-66 |
Number of pages | 11 |
Journal | Nature Genetics |
Volume | 48 |
Issue number | 8 |
Early online date | 20 Jun 2016 |
DOIs | |
Publication status | Published - Aug 2016 |
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Dive into the research topics of 'Meta-analysis of 375,000 individuals identifies 38 susceptibility loci for migraine'. Together they form a unique fingerprint.Projects
- 3 Finished
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MRC UoB UNITE Unit - programme 3
Timpson, N. J. (Principal Investigator) & Timpson, N. J. (Principal Investigator)
1/06/13 → 31/03/18
Project: Research
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MRC UoB UNITE Unit - Programme 1
Davey Smith, G. (Principal Investigator)
1/06/13 → 31/03/18
Project: Research
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CENTRE FOR CASUAL ANALYSES IN TRANSLATIONAL EPIDEMIOLOGY (CAiTE)
Davey Smith, G. (Principal Investigator)
1/09/07 → 1/09/13
Project: Research
Profiles
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Professor George Davey Smith
- MRC Integrative Epidemiology Unit
- Bristol Medical School (PHS) - Professor of Clinical Epidemiology
Person: Academic , Member, Group lead
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Professor Evangelia Stergiakouli
- Bristol Medical School (PHS) - Professor of Genetic Epidemiology and Public Mental Health
- Bristol Population Health Science Institute
- MRC Integrative Epidemiology Unit
Person: Academic , Member