Meta-analysis of Genome-Wide Association Studies for Extraversion: Findings from the Genetics of Personality Consortium

Stéphanie M van den Berg; Marleen H M de Moor; Karin J H Verweij; Robert F Krueger; Michelle Luciano; Alejandro Arias Vasquez; Lindsay K Matteson; Jaime Derringer; Tõnu Esko; Najaf Amin; Scott D Gordon; Narelle K Hansell; Amy B Hart; Ilkka Seppälä; Jennifer E Huffman; Bettina Konte; Jari Lahti; Minyoung Lee; Mike Miller; Teresa Nutile; Toshiko Tanaka; Alexander Teumer; Alexander Viktorin; Juho Wedenoja; Abdel Abdellaoui; Goncalo R Abecasis; Daniel E Adkins; Arpana Agrawal; Jüri Allik; Katja Appel; Timothy B Bigdeli; Fabio Busonero; Harry Campbell; Paul T Costa; George Davey Smith; Gail Davies; Harriet de Wit; Jun Ding; Barbara E Engelhardt; Johan G Eriksson; Iryna O Fedko; Luigi Ferrucci; Barbara Franke; Ina Giegling; Richard Grucza; John P Kemp; Sarah E Medland; Beate St Pourcain; Nicholas J Timpson; David M Evans; Generation Scotland

doi:10.1007/s10519-015-9735-5

Meta-analysis of Genome-Wide Association Studies for Extraversion: Findings from the Genetics of Personality Consortium

Stéphanie M van den Berg, Marleen H M de Moor, Karin J H Verweij, Robert F Krueger, Michelle Luciano, Alejandro Arias Vasquez, Lindsay K Matteson, Jaime Derringer, Tõnu Esko, Najaf Amin, Scott D Gordon, Narelle K Hansell, Amy B Hart, Ilkka Seppälä, Jennifer E Huffman, Bettina Konte, Jari Lahti, Minyoung Lee, Mike Miller, Teresa NutileToshiko Tanaka, Alexander Teumer, Alexander Viktorin, Juho Wedenoja, Abdel Abdellaoui, Goncalo R Abecasis, Daniel E Adkins, Arpana Agrawal, Jüri Allik, Katja Appel, Timothy B Bigdeli, Fabio Busonero, Harry Campbell, Paul T Costa, George Davey Smith, Gail Davies, Harriet de Wit, Jun Ding, Barbara E Engelhardt, Johan G Eriksson, Iryna O Fedko, Luigi Ferrucci, Barbara Franke, Ina Giegling, Richard Grucza, John P Kemp, Sarah E Medland, Beate St Pourcain, Nicholas J Timpson, David M Evans, Generation Scotland

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Abstract

Extraversion is a relatively stable and heritable personality trait associated with numerous psychosocial, lifestyle and health outcomes. Despite its substantial heritability, no genetic variants have been detected in previous genome-wide association (GWA) studies, which may be due to relatively small sample sizes of those studies. Here, we report on a large meta-analysis of GWA studies for extraversion in 63,030 subjects in 29 cohorts. Extraversion item data from multiple personality inventories were harmonized across inventories and cohorts. No genome-wide significant associations were found at the single nucleotide polymorphism (SNP) level but there was one significant hit at the gene level for a long non-coding RNA site (LOC101928162). Genome-wide complex trait analysis in two large cohorts showed that the additive variance explained by common SNPs was not significantly different from zero, but polygenic risk scores, weighted using linkage information, significantly predicted extraversion scores in an independent cohort. These results show that extraversion is a highly polygenic personality trait, with an architecture possibly different from other complex human traits, including other personality traits. Future studies are required to further determine which genetic variants, by what modes of gene action, constitute the heritable nature of extraversion.

Original language	English
Pages (from-to)	170-182
Number of pages	13
Journal	Behavior Genetics
Volume	46
Issue number	2
Early online date	11 Sept 2015
DOIs	https://doi.org/10.1007/s10519-015-9735-5
Publication status	Published - Mar 2016

Keywords

Personality
Phenotype harmonization
Common genetic variants
Imputation
Polygenic risk

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s10519-015-9735-5

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MRC UoB UNITE Unit - programme 3
Timpson, N. J. (Principal Investigator) & Timpson, N. J. (Principal Investigator)
1/06/13 → 31/03/18
Project: Research
MRC UoB UNITE Unit - Programme 1
Davey Smith, G. (Principal Investigator)
1/06/13 → 31/03/18
Project: Research

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van den Berg, S. M., de Moor, M. H. M., Verweij, K. J. H., Krueger, R. F., Luciano, M., Arias Vasquez, A., Matteson, L. K., Derringer, J., Esko, T., Amin, N., Gordon, S. D., Hansell, N. K., Hart, A. B., Seppälä, I., Huffman, J. E., Konte, B., Lahti, J., Lee, M., Miller, M., ... Generation Scotland (2016). Meta-analysis of Genome-Wide Association Studies for Extraversion: Findings from the Genetics of Personality Consortium. Behavior Genetics, 46(2), 170-182. https://doi.org/10.1007/s10519-015-9735-5

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title = "Meta-analysis of Genome-Wide Association Studies for Extraversion: Findings from the Genetics of Personality Consortium",

abstract = "Extraversion is a relatively stable and heritable personality trait associated with numerous psychosocial, lifestyle and health outcomes. Despite its substantial heritability, no genetic variants have been detected in previous genome-wide association (GWA) studies, which may be due to relatively small sample sizes of those studies. Here, we report on a large meta-analysis of GWA studies for extraversion in 63,030 subjects in 29 cohorts. Extraversion item data from multiple personality inventories were harmonized across inventories and cohorts. No genome-wide significant associations were found at the single nucleotide polymorphism (SNP) level but there was one significant hit at the gene level for a long non-coding RNA site (LOC101928162). Genome-wide complex trait analysis in two large cohorts showed that the additive variance explained by common SNPs was not significantly different from zero, but polygenic risk scores, weighted using linkage information, significantly predicted extraversion scores in an independent cohort. These results show that extraversion is a highly polygenic personality trait, with an architecture possibly different from other complex human traits, including other personality traits. Future studies are required to further determine which genetic variants, by what modes of gene action, constitute the heritable nature of extraversion.",

keywords = "Personality, Phenotype harmonization, Common genetic variants, Imputation, Polygenic risk",

author = "{van den Berg}, {St{\'e}phanie M} and {de Moor}, {Marleen H M} and Verweij, {Karin J H} and Krueger, {Robert F} and Michelle Luciano and {Arias Vasquez}, Alejandro and Matteson, {Lindsay K} and Jaime Derringer and T{\~o}nu Esko and Najaf Amin and Gordon, {Scott D} and Hansell, {Narelle K} and Hart, {Amy B} and Ilkka Sepp{\"a}l{\"a} and Huffman, {Jennifer E} and Bettina Konte and Jari Lahti and Minyoung Lee and Mike Miller and Teresa Nutile and Toshiko Tanaka and Alexander Teumer and Alexander Viktorin and Juho Wedenoja and Abdel Abdellaoui and Abecasis, {Goncalo R} and Adkins, {Daniel E} and Arpana Agrawal and J{\"u}ri Allik and Katja Appel and Bigdeli, {Timothy B} and Fabio Busonero and Harry Campbell and Costa, {Paul T} and Smith, {George Davey} and Gail Davies and {de Wit}, Harriet and Jun Ding and Engelhardt, {Barbara E} and Eriksson, {Johan G} and Fedko, {Iryna O} and Luigi Ferrucci and Barbara Franke and Ina Giegling and Richard Grucza and Kemp, {John P} and Medland, {Sarah E} and {St Pourcain}, Beate and Timpson, {Nicholas J} and Evans, {David M} and {Generation Scotland}",

year = "2016",

month = mar,

doi = "10.1007/s10519-015-9735-5",

language = "English",

volume = "46",

pages = "170--182",

journal = "Behavior Genetics",

issn = "0001-8244",

publisher = "Springer, New York, NY",

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van den Berg, SM, de Moor, MHM, Verweij, KJH, Krueger, RF, Luciano, M, Arias Vasquez, A, Matteson, LK, Derringer, J, Esko, T, Amin, N, Gordon, SD, Hansell, NK, Hart, AB, Seppälä, I, Huffman, JE, Konte, B, Lahti, J, Lee, M, Miller, M, Nutile, T, Tanaka, T, Teumer, A, Viktorin, A, Wedenoja, J, Abdellaoui, A, Abecasis, GR, Adkins, DE, Agrawal, A, Allik, J, Appel, K, Bigdeli, TB, Busonero, F, Campbell, H, Costa, PT, Smith, GD, Davies, G, de Wit, H, Ding, J, Engelhardt, BE, Eriksson, JG, Fedko, IO, Ferrucci, L, Franke, B, Giegling, I, Grucza, R, Kemp, JP, Medland, SE, St Pourcain, B , Timpson, NJ, Evans, DM & Generation Scotland 2016, 'Meta-analysis of Genome-Wide Association Studies for Extraversion: Findings from the Genetics of Personality Consortium', Behavior Genetics, vol. 46, no. 2, pp. 170-182. https://doi.org/10.1007/s10519-015-9735-5

TY - JOUR

T1 - Meta-analysis of Genome-Wide Association Studies for Extraversion

T2 - Findings from the Genetics of Personality Consortium

AU - van den Berg, Stéphanie M

AU - de Moor, Marleen H M

AU - Verweij, Karin J H

AU - Krueger, Robert F

AU - Luciano, Michelle

AU - Arias Vasquez, Alejandro

AU - Matteson, Lindsay K

AU - Derringer, Jaime

AU - Esko, Tõnu

AU - Amin, Najaf

AU - Gordon, Scott D

AU - Hansell, Narelle K

AU - Hart, Amy B

AU - Seppälä, Ilkka

AU - Huffman, Jennifer E

AU - Konte, Bettina

AU - Lahti, Jari

AU - Lee, Minyoung

AU - Miller, Mike

AU - Nutile, Teresa

AU - Tanaka, Toshiko

AU - Teumer, Alexander

AU - Viktorin, Alexander

AU - Wedenoja, Juho

AU - Abdellaoui, Abdel

AU - Abecasis, Goncalo R

AU - Adkins, Daniel E

AU - Agrawal, Arpana

AU - Allik, Jüri

AU - Appel, Katja

AU - Bigdeli, Timothy B

AU - Busonero, Fabio

AU - Campbell, Harry

AU - Costa, Paul T

AU - Smith, George Davey

AU - Davies, Gail

AU - de Wit, Harriet

AU - Ding, Jun

AU - Engelhardt, Barbara E

AU - Eriksson, Johan G

AU - Fedko, Iryna O

AU - Ferrucci, Luigi

AU - Franke, Barbara

AU - Giegling, Ina

AU - Grucza, Richard

AU - Kemp, John P

AU - Medland, Sarah E

AU - St Pourcain, Beate

AU - Timpson, Nicholas J

AU - Evans, David M

AU - Generation Scotland

PY - 2016/3

Y1 - 2016/3

N2 - Extraversion is a relatively stable and heritable personality trait associated with numerous psychosocial, lifestyle and health outcomes. Despite its substantial heritability, no genetic variants have been detected in previous genome-wide association (GWA) studies, which may be due to relatively small sample sizes of those studies. Here, we report on a large meta-analysis of GWA studies for extraversion in 63,030 subjects in 29 cohorts. Extraversion item data from multiple personality inventories were harmonized across inventories and cohorts. No genome-wide significant associations were found at the single nucleotide polymorphism (SNP) level but there was one significant hit at the gene level for a long non-coding RNA site (LOC101928162). Genome-wide complex trait analysis in two large cohorts showed that the additive variance explained by common SNPs was not significantly different from zero, but polygenic risk scores, weighted using linkage information, significantly predicted extraversion scores in an independent cohort. These results show that extraversion is a highly polygenic personality trait, with an architecture possibly different from other complex human traits, including other personality traits. Future studies are required to further determine which genetic variants, by what modes of gene action, constitute the heritable nature of extraversion.

AB - Extraversion is a relatively stable and heritable personality trait associated with numerous psychosocial, lifestyle and health outcomes. Despite its substantial heritability, no genetic variants have been detected in previous genome-wide association (GWA) studies, which may be due to relatively small sample sizes of those studies. Here, we report on a large meta-analysis of GWA studies for extraversion in 63,030 subjects in 29 cohorts. Extraversion item data from multiple personality inventories were harmonized across inventories and cohorts. No genome-wide significant associations were found at the single nucleotide polymorphism (SNP) level but there was one significant hit at the gene level for a long non-coding RNA site (LOC101928162). Genome-wide complex trait analysis in two large cohorts showed that the additive variance explained by common SNPs was not significantly different from zero, but polygenic risk scores, weighted using linkage information, significantly predicted extraversion scores in an independent cohort. These results show that extraversion is a highly polygenic personality trait, with an architecture possibly different from other complex human traits, including other personality traits. Future studies are required to further determine which genetic variants, by what modes of gene action, constitute the heritable nature of extraversion.

KW - Personality

KW - Phenotype harmonization

KW - Common genetic variants

KW - Imputation

KW - Polygenic risk

U2 - 10.1007/s10519-015-9735-5

DO - 10.1007/s10519-015-9735-5

M3 - Article (Academic Journal)

C2 - 26362575

SN - 0001-8244

VL - 46

SP - 170

EP - 182

JO - Behavior Genetics

JF - Behavior Genetics

IS - 2

ER -

Meta-analysis of Genome-Wide Association Studies for Extraversion: Findings from the Genetics of Personality Consortium

Abstract

Keywords

UN SDGs

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Projects

MRC UoB UNITE Unit - programme 3

MRC UoB UNITE Unit - Programme 1

Cite this