Meta-analysis of vitamin D receptor polymorphisms and pulmonary tuberculosis risk

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Abstract

Several case-control studies performed in populations where the incidence of tuberculosis (TB) is high have examined genetic susceptibility to TB. The Vitamin D receptor (VDR) gene is a good candidate, because it influences immune response, and associations between TaqI and FokI polymorphisms in the VDR gene and pulmonary TB risk have been found. Furthermore, if a relationship between these polymorphisms and TB risk is confirmed this will be important evidence pointing to vitamin D as a potential preventive agent for TB. We carried out a systematic review and meta-analysis, and found that results were inconclusive and studies were underpowered.
Translated title of the contributionMeta-analysis of vitamin D receptor polymorphisms and pulmonary tuberculosis risk
Original languageEnglish
Pages (from-to)1174 - 1177
Number of pages4
JournalInternational Journal of Tuberculosis and Lung Disease
Volume9 (10)
Publication statusPublished - Oct 2005

Bibliographical note

Publisher: International Union Against Tuberculosis and Lung Disease

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