Metabolically healthy obesity and risk of incident type 2 diabetes: a meta-analysis of prospective cohort studies

J A Bell, M Kivimaki, M Hamer

Research output: Contribution to journalArticle (Academic Journal)peer-review

258 Citations (Scopus)

Abstract

The risk of type 2 diabetes among obese adults who are metabolically healthy has not been established. We systematically searched Medline (1946-August 2013) and Embase (1947-August 2013) for prospective studies of type 2 diabetes incidence (defined by blood glucose levels or self-report) among metabolically healthy obese adults (defined by body mass index [BMI] and normal cardiometabolic clustering, insulin profile or risk score) aged ≥18 years at baseline. We supplemented the analysis with an original effect estimate from the English Longitudinal Study of Ageing (ELSA), with metabolically healthy obesity defined as BMI ≥ 30 kg m(-2) and <2 of hypertension, impaired glycaemic control, systemic inflammation, adverse high-density lipoprotein cholesterol and adverse triglycerides. Estimates from seven published studies and ELSA were pooled using random effects meta-analyses (1,770 healthy obese participants; 98 type 2 diabetes cases). The pooled adjusted relative risk (RR) for incident type 2 diabetes was 4.03 (95% confidence interval = 2.66-6.09) in healthy obese adults and 8.93 (6.86-11.62) in unhealthy obese compared with healthy normal-weight adults. Although there was between-study heterogeneity in the size of effects (I(2)  = 49.8%; P = 0.03), RR for healthy obesity exceeded one in every study, indicating a consistently increased risk across study populations. Metabolically healthy obese adults show a substantially increased risk of developing type 2 diabetes compared with metabolically healthy normal-weight adults. Prospective evidence does not indicate that healthy obesity is a harmless condition.

Original languageEnglish
Pages (from-to)504-15
Number of pages12
JournalObesity Reviews
Volume15
Issue number6
DOIs
Publication statusPublished - Jun 2014

Keywords

  • Aging
  • Blood Glucose
  • Body Mass Index
  • C-Reactive Protein
  • Cholesterol, HDL
  • Cohort Studies
  • Diabetes Mellitus, Type 2
  • Female
  • Hemoglobin A, Glycosylated
  • Humans
  • Hypertension
  • Longitudinal Studies
  • MEDLINE
  • Male
  • Obesity
  • Prospective Studies
  • Risk
  • Risk Factors
  • Triglycerides

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