Metabolomics: a valuable tool for stem cell monitoring in regenerative medicine

Laura E. McNamara*, Terje Sjöström, R. M. Dominic Meek, Richard O. C. Oreffo, Bo Su, Matthew J. Dalby, Karl E. V. Burgess

*Corresponding author for this work

Research output: Contribution to journalReview article (Academic Journal)peer-review

22 Citations (Scopus)

Abstract

Metabolomics is a method for investigation of changes in the global metabolite profile of cells. This paper discusses the technical application of the approach, considering metabolite extraction, separation, mass spectrometry and data interpretation. A particular focus is on the application of metabolomics to the study of stem cell physiology in the context of biomaterials and regenerative medicine. Case studies are used to illustrate key points, focusing on the use of metabolomics in the examination of mesenchymal stem cell responses to titania-nanopillared substrata designed for orthopaedic applications.

Original languageEnglish
Pages (from-to)1713-1724
Number of pages12
JournalJournal of the Royal Society Interface
Volume9
Issue number73
DOIs
Publication statusPublished - 7 Aug 2012

Keywords

  • biomaterials
  • MASS-SPECTROMETRY DATA
  • regenerative medicine
  • DIFFERENTIATION
  • CHROMATOGRAPHY
  • PROFILE
  • stem cells
  • mass spectrometry
  • titanium
  • IDENTIFICATION
  • EXPRESSION
  • TENSION
  • metabolomics

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