Metabolomics of aging requires large-scale longitudinal studies with replication

Ville Petteri Mäkinen; Mika Ala-Korpela

doi:10.1073/pnas.1607062113

Metabolomics of aging requires large-scale longitudinal studies with replication

Ville Petteri Mäkinen^*, Mika Ala-Korpela

^*Corresponding author for this work

Bristol Medical School (PHS)

Research output: Contribution to journal › Letter (Academic Journal) › peer-review

22 Citations (Scopus)

247 Downloads (Pure)

Abstract

Aging is a complex biological process with remarkable individual variation and manifests also as changes in systemic metabolism. In a recent paper in PNAS, Chaleckis et al. (1) studied a set of blood metabolites in old and young individuals. The work was thorough in the methodological aspects regarding the mass spectrometry of circulating molecules in plasma, red blood cells, and whole blood. However, we find it alarming that the results and interpretations on the suggested age-related metabolic differences were not properly put into epidemiological context. We therefore draw attention to four key issues: (i) metabolic heterogeneity of…

Original language	English
Article number	E3470
Number of pages	1
Journal	Proceedings of the National Academy of Sciences of the United States of America
Volume	113
Issue number	25
Early online date	14 Jun 2016
DOIs	https://doi.org/10.1073/pnas.1607062113
Publication status	Published - 21 Jun 2016

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abstract = "Aging is a complex biological process with remarkable individual variation and manifests also as changes in systemic metabolism. In a recent paper in PNAS, Chaleckis et al. (1) studied a set of blood metabolites in old and young individuals. The work was thorough in the methodological aspects regarding the mass spectrometry of circulating molecules in plasma, red blood cells, and whole blood. However, we find it alarming that the results and interpretations on the suggested age-related metabolic differences were not properly put into epidemiological context. We therefore draw attention to four key issues: (i) metabolic heterogeneity of…",

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Metabolomics of aging requires large-scale longitudinal studies with replication

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Metabolomics of aging requires large-scale longitudinal studies with replication

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