Metabolomics of aging requires large-scale longitudinal studies with replication

Ville Petteri Mäkinen*, Mika Ala-Korpela

*Corresponding author for this work

Research output: Contribution to journalLetter (Academic Journal)peer-review

16 Citations (Scopus)
224 Downloads (Pure)


Aging is a complex biological process with remarkable individual variation and manifests also as changes in systemic metabolism. In a recent paper in PNAS, Chaleckis et al. (1) studied a set of blood metabolites in old and young individuals. The work was thorough in the methodological aspects regarding the mass spectrometry of circulating molecules in plasma, red blood cells, and whole blood. However, we find it alarming that the results and interpretations on the suggested age-related metabolic differences were not properly put into epidemiological context. We therefore draw attention to four key issues: (i) metabolic heterogeneity of…
Original languageEnglish
Article numberE3470
Number of pages1
JournalProceedings of the National Academy of Sciences of the United States of America
Issue number25
Early online date14 Jun 2016
Publication statusPublished - 21 Jun 2016


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