Metabotropic action of postsynaptic kainate receptors triggers hippocampal long-term potentiation

Milos Petrovic, Silvia Viana da Silva, James P Clement, Ladislav Vyklicky, Christopher Mulle, Maria Inmaculada Gonzalez, Jeremy M Henley

Research output: Contribution to journalArticle (Academic Journal)peer-review

25 Citations (Scopus)
318 Downloads (Pure)

Abstract

Long-term potentiation (LTP) in the rat hippocampus is the most extensively studied cellular model for learning and memory. Induction of classical LTP involves an NMDA-receptor- and calcium-dependent increase in functional synaptic AMPA receptors, mediated by enhanced recycling of internalized AMPA receptors back to the postsynaptic membrane. Here we report a physiologically relevant NMDA-receptor-independent mechanism that drives increased AMPA receptor recycling and LTP. This pathway requires the metabotropic action of kainate receptors and activation of G protein, protein kinase C and phospholipase C. Like classical LTP, kainate-receptor-dependent LTP recruits recycling endosomes to spines, enhances synaptic recycling of AMPA receptors to increase their surface expression and elicits structural changes in spines, including increased growth and maturation. These data reveal a new and, to our knowledge, previously unsuspected role for postsynaptic kainate receptors in the induction of functional and structural plasticity in the hippocampus.
Original languageEnglish
Pages (from-to)529–539
Number of pages11
JournalNature Neuroscience
Volume20
Issue number4
Early online date13 Feb 2017
DOIs
Publication statusPublished - Apr 2017

Keywords

  • Hippocampus
  • Long-term potentiation
  • Membrane proteins

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