Metal binding to a zinc-finger peptide: A comparison between solution and the gas phase.

Y Berezovskaya; CT Armstrong; AL Boyle; M Porrini; DN Woolfson; PE Barran

doi:10.1039/C0CC02445G

Metal binding to a zinc-finger peptide: A comparison between solution and the gas phase.

Y Berezovskaya, CT Armstrong, AL Boyle, M Porrini, DN Woolfson, PE Barran

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Abstract

Solution-phase spectroscopy and mass spectrometry are used to probe interactions between divalent metal ions and a synthetic Cys2His2 zinc-finger peptide (vCP1). Both methods provide the same order of binding affinity, zinc Z cobalt c copper c calcium. Collision-cross-section measurements show that both apo and holo forms are compact. This is corroborated by molecular-dynamics simulations.

Translated title of the contribution	Metal Binding to a zinc-finger peptide: a comparison between solution and gas phase
Original language	English
Pages (from-to)	412-414
Number of pages	3
Journal	Chemical Communications
Volume	47
Issue number	1
DOIs	https://doi.org/10.1039/C0CC02445G
Publication status	Published - 1 Jan 2011

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@article{09d5fbe855784d40bec0ed713e3a58bd,

title = "Metal binding to a zinc-finger peptide: A comparison between solution and the gas phase.",

abstract = "Solution-phase spectroscopy and mass spectrometry are used to probe interactions between divalent metal ions and a synthetic Cys2His2 zinc-finger peptide (vCP1). Both methods provide the same order of binding affinity, zinc Z cobalt c copper c calcium. Collision-cross-section measurements show that both apo and holo forms are compact. This is corroborated by molecular-dynamics simulations.",

author = "Y Berezovskaya and CT Armstrong and AL Boyle and M Porrini and DN Woolfson and PE Barran",

year = "2011",

month = jan,

day = "1",

doi = "10.1039/C0CC02445G",

language = "English",

volume = "47",

pages = "412--414",

journal = "Chemical Communications",

issn = "1359-7345",

publisher = "Royal Society of Chemistry",

number = "1",

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TY - JOUR

T1 - Metal binding to a zinc-finger peptide

T2 - A comparison between solution and the gas phase.

AU - Berezovskaya, Y

AU - Armstrong, CT

AU - Boyle, AL

AU - Porrini, M

AU - Woolfson, DN

AU - Barran, PE

PY - 2011/1/1

Y1 - 2011/1/1

N2 - Solution-phase spectroscopy and mass spectrometry are used to probe interactions between divalent metal ions and a synthetic Cys2His2 zinc-finger peptide (vCP1). Both methods provide the same order of binding affinity, zinc Z cobalt c copper c calcium. Collision-cross-section measurements show that both apo and holo forms are compact. This is corroborated by molecular-dynamics simulations.

AB - Solution-phase spectroscopy and mass spectrometry are used to probe interactions between divalent metal ions and a synthetic Cys2His2 zinc-finger peptide (vCP1). Both methods provide the same order of binding affinity, zinc Z cobalt c copper c calcium. Collision-cross-section measurements show that both apo and holo forms are compact. This is corroborated by molecular-dynamics simulations.

U2 - 10.1039/C0CC02445G

DO - 10.1039/C0CC02445G

M3 - Article (Academic Journal)

C2 - 20852793

SN - 1359-7345

VL - 47

SP - 412

EP - 414

JO - Chemical Communications

JF - Chemical Communications

IS - 1

ER -

Metal binding to a zinc-finger peptide: A comparison between solution and the gas phase.

Abstract

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