Metal Binding to a zinc-finger peptide: a comparison between solution and gas phase

Y Berezovskaya, CT Armstrong, AL Boyle, M Porrini, DN Woolfson, PE Barran

Research output: Non-textual formWeb publication/site

26 Citations (Scopus)

Abstract

Solution-phase spectroscopy and mass spectrometry are used to probe interactions between divalent metal ions and a synthetic Cys2His2 zinc-finger peptide (vCP1). Both methods provide the same order of binding affinity, zinc Z cobalt c copper c calcium. Collision-cross-section measurements show that both apo and holo forms are compact. This is corroborated by molecular-dynamics simulations.
Translated title of the contributionMetal Binding to a zinc-finger peptide: a comparison between solution and gas phase
Original languageEnglish
EditionChemical Communications
DOIs
Publication statusPublished - 20 Sep 2010

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