Methodological developments in randomized controlled trial-based economic evaluations

Joanna C Thorn*, Sian M Noble, William Hollingworth

*Corresponding author for this work

Research output: Contribution to journalArticle (Academic Journal)peer-review

1 Citation (Scopus)


Economic evaluation is a key contributor to decision making in health care, and it is important that it is carried out as effectively and reliably as possible. Studies carried out alongside randomised controlled trials are required to contribute real-world evidence to the decision-making process. However, the requirement that resource use be measured as well as effectiveness data within a trial results in additional complexity for trialists, and there are a number of methodological areas in which improvement is needed. This article reviews the literature in methodological work carried out to inform economic evaluation studies conducted alongside randomised controlled trials. Recent advances in areas including overall trial design, measuring resource use, measuring outcomes and reporting economic evaluations are discussed.

Original languageEnglish
Pages (from-to)843-856
Number of pages14
JournalExpert Review of Pharmacoeconomics & Outcomes Research
Issue number6
Publication statusPublished - 1 Dec 2014

Structured keywords

  • ConDuCT-II


  • Clinical trial
  • Cost
  • Economic evaluation
  • EQ-5D
  • Health-related quality of life
  • Randomised controlled trial
  • Resource-use measurement
  • Utility measurement

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