Methods Explained: Multilevel network meta-regression

For this edition of “Methods Explained,” I have spoken to 2 experts who play an important role in the adoption of multilevel network meta-regression (ML-NMR) in the field of health economics and outcomes research (HEOR). Jeroen Jansen, PhD is an Associate Professor at the Department of Clinical Pharmacy of the University of California, San Francisco and Chief Scientist, HEOR at the Precision Medicine Group. Drawing on methods used in ecology, Jeroen first introduced a precursor to ML-NMR back in 2012. David Phillippo, PhD is a Research Fellow in Evidence Synthesis at the Bristol Medical School of the University of Bristol. David generalized Jeroen’s ideas into the ML-NMR framework and is the author of the multinma R package, which is playing an important role in the broader adoption of ML-NMR.