Methods for 2-Deoxyglycoside Synthesis

Clay S. Bennett*, M. Carmen Galan

*Corresponding author for this work

Research output: Contribution to journalArticle (Academic Journal)peer-review

103 Citations (Scopus)
276 Downloads (Pure)

Abstract

Deoxy-sugars often play a critical role in modulating the potency of many bioactive natural products. Accordingly, there has been sustained interest in methods for their synthesis over the past several decades. The focus of much of this work has been on developing new glycosylation reactions that permit the mild and selective construction of deoxyglycosides. This Review covers classical approaches to deoxyglycoside synthesis, as well as more recently developed chemistry that aims to control the selectivity of the reaction through rational design of the promoter. Where relevant, the application of this chemistry to natural product synthesis will also be described.

Original languageEnglish
Pages (from-to)7931-7985
Number of pages55
JournalChemical Reviews
Volume118
Issue number17
Early online date28 Jun 2018
DOIs
Publication statusPublished - 2018

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