AP Hollander (Inventor), W Kafienah (Inventor)

Research output: Patent


The invention relates to the use of parathyroid hormone-related protein (PTHrP) in the prevention of hypertrophy in chondrogenic cells for cartilage replacement. A method for engineering three dimensional cartilage constructs from chondrogenic cells is provided, said method comprising a step of treating the chondrogenic cells or immature constructs with PTHrP to regulate hypertrophy. Also provided are: three dimensional cartilage produced by the method of the invention, and an engineered cartilage construct comprising chondrogenic cells and a bioactive scaffold capable of controlled release of PTHrP. In addition, the invention provides a method for the treatment of osteoarthritis.
Translated title of the contributionMETHODS FOR TISSUE ENGINEERING
Original languageEnglish
Patent numberWO/2007/003958
Publication statusPublished - 11 Jan 2007


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