METTL3 Regulates Angiogenesis by Modulating let-7e-5p and miRNA-18a-5p Expression in Endothelial Cells

Aránzazu Chamorro-Jorganes; Walid K Sweaad; Rajesh Katare; Marie Besnier; Maryam Anwar; N Beazley-Long; Graciela Sala-Newby; Iñigo Ruiz-Polo; Dhananjie Chandrasekera; Alison A Ritchie; Andrew V Benest; Costanza Emanueli

doi:10.1161/ATVBAHA.121.316180

METTL3 Regulates Angiogenesis by Modulating let-7e-5p and miRNA-18a-5p Expression in Endothelial Cells

Aránzazu Chamorro-Jorganes
, Walid K Sweaad
, Rajesh Katare
, Marie Besnier
, Maryam Anwar
, N Beazley-Long
, Graciela Sala-Newby
, Iñigo Ruiz-Polo
, Dhananjie Chandrasekera
, Alison A Ritchie
, Andrew V Benest
, Costanza Emanueli

Bristol Medical School (THS)

Research output: Contribution to journal › Article (Academic Journal) › peer-review

58 Citations (Scopus)

Abstract

[Figure: see text].

Original language	English
Pages (from-to)	e325-e337
Journal	Arteriosclerosis, Thrombosis, and Vascular Biology
Volume	41
Issue number	6
Early online date	29 Apr 2021
DOIs	https://doi.org/10.1161/ATVBAHA.121.316180
Publication status	Published - Jun 2021

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Adenosine/analogs & derivatives
Animals
Cells, Cultured
Disease Models, Animal
Female
Gene Expression Regulation
Hindlimb/blood supply
Human Umbilical Vein Endothelial Cells/enzymology
Humans
Ischemia/enzymology
Male
Methyltransferases/genetics
Mice, Inbred C57BL
MicroRNAs/genetics
Myocardial Infarction/enzymology
Neovascularization, Physiologic
Signal Transduction
Thrombospondin 1/genetics

Access to Document

10.1161/ATVBAHA.121.316180

Handle.net

Persistent link

Cite this

Chamorro-Jorganes, A., Sweaad, W. K., Katare, R., Besnier, M., Anwar, M., Beazley-Long, N., Sala-Newby, G., Ruiz-Polo, I., Chandrasekera, D., Ritchie, A. A., Benest, A. V., & Emanueli, C. (2021). METTL3 Regulates Angiogenesis by Modulating let-7e-5p and miRNA-18a-5p Expression in Endothelial Cells. Arteriosclerosis, Thrombosis, and Vascular Biology, 41(6), e325-e337. https://doi.org/10.1161/ATVBAHA.121.316180

@article{2008b93460514410badb4d6d8154c58b,

title = "METTL3 Regulates Angiogenesis by Modulating let-7e-5p and miRNA-18a-5p Expression in Endothelial Cells",

abstract = "[Figure: see text].",

keywords = "Adenosine/analogs \& derivatives, Animals, Cells, Cultured, Disease Models, Animal, Female, Gene Expression Regulation, Hindlimb/blood supply, Human Umbilical Vein Endothelial Cells/enzymology, Humans, Ischemia/enzymology, Male, Methyltransferases/genetics, Mice, Inbred C57BL, MicroRNAs/genetics, Myocardial Infarction/enzymology, Neovascularization, Physiologic, Signal Transduction, Thrombospondin 1/genetics",

author = "Ar{\'a}nzazu Chamorro-Jorganes and Sweaad, \{Walid K\} and Rajesh Katare and Marie Besnier and Maryam Anwar and N Beazley-Long and Graciela Sala-Newby and I{\~n}igo Ruiz-Polo and Dhananjie Chandrasekera and Ritchie, \{Alison A\} and Benest, \{Andrew V\} and Costanza Emanueli",

year = "2021",

month = jun,

doi = "10.1161/ATVBAHA.121.316180",

language = "English",

volume = "41",

pages = "e325--e337",

journal = "Arteriosclerosis, Thrombosis, and Vascular Biology",

issn = "1079-5642",

publisher = "Lippincott Williams and Wilkins",

number = "6",

}

Chamorro-Jorganes, A, Sweaad, WK, Katare, R, Besnier, M, Anwar, M, Beazley-Long, N, Sala-Newby, G, Ruiz-Polo, I, Chandrasekera, D, Ritchie, AA, Benest, AV & Emanueli, C 2021, 'METTL3 Regulates Angiogenesis by Modulating let-7e-5p and miRNA-18a-5p Expression in Endothelial Cells', Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 41, no. 6, pp. e325-e337. https://doi.org/10.1161/ATVBAHA.121.316180

TY - JOUR

T1 - METTL3 Regulates Angiogenesis by Modulating let-7e-5p and miRNA-18a-5p Expression in Endothelial Cells

AU - Chamorro-Jorganes, Aránzazu

AU - Sweaad, Walid K

AU - Katare, Rajesh

AU - Besnier, Marie

AU - Anwar, Maryam

AU - Beazley-Long, N

AU - Sala-Newby, Graciela

AU - Ruiz-Polo, Iñigo

AU - Chandrasekera, Dhananjie

AU - Ritchie, Alison A

AU - Benest, Andrew V

AU - Emanueli, Costanza

PY - 2021/6

Y1 - 2021/6

N2 - [Figure: see text].

AB - [Figure: see text].

KW - Adenosine/analogs & derivatives

KW - Animals

KW - Cells, Cultured

KW - Disease Models, Animal

KW - Female

KW - Gene Expression Regulation

KW - Hindlimb/blood supply

KW - Human Umbilical Vein Endothelial Cells/enzymology

KW - Humans

KW - Ischemia/enzymology

KW - Male

KW - Methyltransferases/genetics

KW - Mice, Inbred C57BL

KW - MicroRNAs/genetics

KW - Myocardial Infarction/enzymology

KW - Neovascularization, Physiologic

KW - Signal Transduction

KW - Thrombospondin 1/genetics

U2 - 10.1161/ATVBAHA.121.316180

DO - 10.1161/ATVBAHA.121.316180

M3 - Article (Academic Journal)

C2 - 33910374

SN - 1079-5642

VL - 41

SP - e325-e337

JO - Arteriosclerosis, Thrombosis, and Vascular Biology

JF - Arteriosclerosis, Thrombosis, and Vascular Biology

IS - 6

ER -

METTL3 Regulates Angiogenesis by Modulating let-7e-5p and miRNA-18a-5p Expression in Endothelial Cells

Abstract

UN SDGs

Keywords

Access to Document

Handle.net

Fingerprint

Cite this