MicroRNA-503 and the Extended MicroRNA-16 Family in Angiogenesis

Andrea Caporali; Costanza Emanueli

doi:10.1016/j.tcm.2012.05.003

MicroRNA-503 and the Extended MicroRNA-16 Family in Angiogenesis

Andrea Caporali, Costanza Emanueli

Bristol Medical School (THS)

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Abstract

MicroRNAs (miRs) are post-transcriptional inhibitory regulators of gene expression acting by direct binding to complementary messenger RNA (mRNA) transcripts. Recent studies have demonstrated that miRs are crucial determinants of endothelial cell behavior and angiogenesis. We have provided evidence of the prominent role of miR-503 in impairment of postischemic reparative angiogenesis in the setting of diabetes. Because miR-503 belongs to the miR-16 extended family of miRs, in this review, we describe the cardiovascular functions of miR-503 and other members of the miR-16 family and their impact on angiogenesis.

Original language	English
Pages (from-to)	162-6
Number of pages	5
Journal	Trends in Cardiovascular Medicine
Volume	21
Issue number	6
DOIs	https://doi.org/10.1016/j.tcm.2012.05.003
Publication status	Published - 2011

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title = "MicroRNA-503 and the Extended MicroRNA-16 Family in Angiogenesis",

abstract = "MicroRNAs (miRs) are post-transcriptional inhibitory regulators of gene expression acting by direct binding to complementary messenger RNA (mRNA) transcripts. Recent studies have demonstrated that miRs are crucial determinants of endothelial cell behavior and angiogenesis. We have provided evidence of the prominent role of miR-503 in impairment of postischemic reparative angiogenesis in the setting of diabetes. Because miR-503 belongs to the miR-16 extended family of miRs, in this review, we describe the cardiovascular functions of miR-503 and other members of the miR-16 family and their impact on angiogenesis.",

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AU - Emanueli, Costanza

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AB - MicroRNAs (miRs) are post-transcriptional inhibitory regulators of gene expression acting by direct binding to complementary messenger RNA (mRNA) transcripts. Recent studies have demonstrated that miRs are crucial determinants of endothelial cell behavior and angiogenesis. We have provided evidence of the prominent role of miR-503 in impairment of postischemic reparative angiogenesis in the setting of diabetes. Because miR-503 belongs to the miR-16 extended family of miRs, in this review, we describe the cardiovascular functions of miR-503 and other members of the miR-16 family and their impact on angiogenesis.

U2 - 10.1016/j.tcm.2012.05.003

DO - 10.1016/j.tcm.2012.05.003

M3 - Article (Academic Journal)

C2 - 22814423

SN - 1873-2615

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EP - 166

JO - Trends in Cardiovascular Medicine

JF - Trends in Cardiovascular Medicine

IS - 6

ER -

MicroRNA-503 and the Extended MicroRNA-16 Family in Angiogenesis

Abstract

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