MicroRNA-503 and the Extended MicroRNA-16 Family in Angiogenesis

Andrea Caporali, Costanza Emanueli

Research output: Contribution to journalArticle (Academic Journal)peer-review

62 Citations (Scopus)

Abstract

MicroRNAs (miRs) are post-transcriptional inhibitory regulators of gene expression acting by direct binding to complementary messenger RNA (mRNA) transcripts. Recent studies have demonstrated that miRs are crucial determinants of endothelial cell behavior and angiogenesis. We have provided evidence of the prominent role of miR-503 in impairment of postischemic reparative angiogenesis in the setting of diabetes. Because miR-503 belongs to the miR-16 extended family of miRs, in this review, we describe the cardiovascular functions of miR-503 and other members of the miR-16 family and their impact on angiogenesis.
Original languageEnglish
Pages (from-to)162-6
Number of pages5
JournalTrends in Cardiovascular Medicine
Volume21
Issue number6
DOIs
Publication statusPublished - 2011

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