Microvascular ischemia in hypertrophic cardiomyopathy: new insights from high-resolution combined quantification of perfusion and late gadolinium enhancement

Adriana D M Villa, Eva Sammut, Niloufar Zarinabad, Gerald Carr-White, Jack Lee, Nuno Bettencourt, Reza Razavi, Eike Nagel, Amedeo Chiribiri

Research output: Contribution to journalArticle (Academic Journal)peer-review

43 Citations (Scopus)
172 Downloads (Pure)



Microvascular ischemia is one of the hallmarks of hypertrophic cardiomyopathy (HCM) and has been associated with poor outcome. However, myocardial fibrosis, seen on cardiovascular magnetic resonance (CMR) as late gadolinium enhancement (LGE), can be responsible for rest perfusion defects in up to 30% of patients with HCM, potentially leading to an overestimation of the ischemic burden. We investigated the effect of left ventricle (LV) scar on the total LV ischemic burden using novel high-resolution perfusion analysis techniques in conjunction with LGE quantification.


30 patients with HCM and unobstructed epicardial coronary arteries underwent CMR with Fermi constrained quantitative perfusion analysis on segmental and high-resolution data. The latter were corrected for the presence of fibrosis on a pixel-by-pixel basis.


High-resolution quantification proved more sensitive for the detection of microvascular ischemia in comparison to segmental analysis. Areas of LGE were associated with significant reduction of myocardial perfusion reserve (MPR) leading to an overestimation of the total ischemic burden on non-corrected perfusion maps. Using a threshold MPR of 1.5, the presence of LGE caused an overestimation of the ischemic burden of 28%. The ischemic burden was more severe in patients with fibrosis, also after correction of the perfusion maps, in keeping with more severe disease in this subgroup.


LGE is an important confounder in the assessment of the ischemic burden in patients with HCM. High-resolution quantitative analysis with LGE correction enables the independent evaluation of microvascular ischemia and fibrosis and should be used when evaluating patients with HCM.

Original languageEnglish
Article number4 (2016)
Number of pages11
JournalJournal of Cardiovascular Magnetic Resonance
Publication statusPublished - 14 Jan 2016


  • Aged
  • Cardiomyopathy, Hypertrophic/diagnosis
  • Cicatrix/diagnosis
  • Contrast Media
  • Coronary Circulation
  • Feasibility Studies
  • Female
  • Fibrosis
  • Humans
  • Hyperemia/physiopathology
  • Magnetic Resonance Imaging
  • Male
  • Microcirculation
  • Middle Aged
  • Myocardial Ischemia/diagnosis
  • Myocardial Perfusion Imaging/methods
  • Myocardium/pathology
  • Organometallic Compounds
  • Predictive Value of Tests
  • Reproducibility of Results
  • Retrospective Studies


Dive into the research topics of 'Microvascular ischemia in hypertrophic cardiomyopathy: new insights from high-resolution combined quantification of perfusion and late gadolinium enhancement'. Together they form a unique fingerprint.

Cite this