Microvascularity, blood flow and tissue structure at the subchondral plate using an X-ray fluorescence technique

P. Muthuvelu, R. E. Ellis, E. M. Green, D. Attenburrow, R. Barrett, K. Arkill, D. B. Colridge, C. P. Winlove, D. A. Bradley*

*Corresponding author for this work

Research output: Contribution to journalArticle (Academic Journal)peer-review

3 Citations (Scopus)


The measurement of blood flow and blood in bone and cartilaginous tissues is crucial to understanding of the development of various diseases, but it presents a formidable technical challenge. We have therefore developed a method based on the detection of metallized microspheres using X-ray fluorescence. This approach provides unrivalled sensitivity and spatial resolution and also allows us simultaneously to measure other markers of the metabolic status of the tissue.

Original languageEnglish
Pages (from-to)771-775
Number of pages5
JournalJournal of Radioanalytical and Nuclear Chemistry
Issue number3
Publication statusPublished - Mar 2007

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