Migration and DNA methylation: a comparison of methylation patterns in type 2 diabetes susceptibility genes between indians and europeans

Hannah R Elliott; Gagandeep Kaur Walia; Aparna Duggirala; Alix Groom; S. Umakar Reddy; Giriraj Ratan Chandak; Vipin Gupta; Markku Laakso; Jacqueline M Dekker; Mark Walker; Shah Ebrahim; George Davey Smith; Caroline L Relton

doi:10.7243/2050-0866-2-6

Migration and DNA methylation: a comparison of methylation patterns in type 2 diabetes susceptibility genes between indians and europeans

Hannah R Elliott, Gagandeep Kaur Walia, Aparna Duggirala, Alix Groom, S. Umakar Reddy, Giriraj Ratan Chandak, Vipin Gupta, Markku Laakso, Jacqueline M Dekker, Mark Walker, Shah Ebrahim, George Davey Smith, Caroline L Relton

Research output: Contribution to journal › Article (Academic Journal) › peer-review

Abstract

Background: Type 2 diabetes is a global problem that is increasingly prevalent in low and middle income countries including India, and is partly attributed to increased urbanisation. Genotype clearly plays a role in type 2 diabetes susceptibility. However, the role of DNA methylation and its interaction with genotype and metabolic measures is poorly understood. This study aimed to establish whether methylation patterns of type 2 diabetes genes differ between distinct Indian and European populations and/or change following rural to urban migration in India.

Methods: Quantitative DNA methylation analysis in Indians and Europeans using Sequenom® EpiTYPER® technology was undertaken in three genes: ADCY5, FTO and KCNJ11. Metabolic measures and genotype data were also analysed.

Results: Consistent differences in DNA methylation patterns were observed between Indian and European populations in ADCY5, FTO and KCNJ11. Associations were demonstrated between FTO rs9939609 and BMI and between ADCY5 rs17295401 and HDL levels in Europeans. However, these observations were not linked to local variation in DNA methylation levels. No differences in methylation patterns were observed in urban-dwelling migrants compared to their non-migrant rural-dwelling siblings in India.

Conclusions: Analysis of DNA methylation at three type 2 diabetes susceptibility loci highlighted geographical and ethnic differences in methylation patterns. These differences may be attributed to genetic and/or region-specific environmental factors.

Original language	English
Journal	Diabetes Research & Clinical Metabolism
DOIs	https://doi.org/10.7243/2050-0866-2-6
Publication status	Published - 2013

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MRC UoB UNITE Unit - Programme 2
Relton, C. L. (Principal Investigator) & Relton, C. L. (Principal Investigator)
1/06/13 → 31/03/18
Project: Research
CENTRE FOR CASUAL ANALYSES IN TRANSLATIONAL EPIDEMIOLOGY (CAiTE)
Davey Smith, G. (Principal Investigator)
1/09/07 → 1/09/13
Project: Research

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Elliott, H. R., Walia, G. K., Duggirala, A., Groom, A., Reddy, S. U., Chandak, G. R., Gupta, V., Laakso, M., Dekker, J. M., Walker, M., Ebrahim, S., Davey Smith, G., & Relton, C. L. (2013). Migration and DNA methylation: a comparison of methylation patterns in type 2 diabetes susceptibility genes between indians and europeans. Diabetes Research & Clinical Metabolism. https://doi.org/10.7243/2050-0866-2-6

@article{4a621755e1be435786db407c7fc59e4c,

title = "Migration and DNA methylation: a comparison of methylation patterns in type 2 diabetes susceptibility genes between indians and europeans",

abstract = "Background: Type 2 diabetes is a global problem that is increasingly prevalent in low and middle income countries including India, and is partly attributed to increased urbanisation. Genotype clearly plays a role in type 2 diabetes susceptibility. However, the role of DNA methylation and its interaction with genotype and metabolic measures is poorly understood. This study aimed to establish whether methylation patterns of type 2 diabetes genes differ between distinct Indian and European populations and/or change following rural to urban migration in India.Methods: Quantitative DNA methylation analysis in Indians and Europeans using Sequenom{\textregistered} EpiTYPER{\textregistered} technology was undertaken in three genes: ADCY5, FTO and KCNJ11. Metabolic measures and genotype data were also analysed.Results: Consistent differences in DNA methylation patterns were observed between Indian and European populations in ADCY5, FTO and KCNJ11. Associations were demonstrated between FTO rs9939609 and BMI and between ADCY5 rs17295401 and HDL levels in Europeans. However, these observations were not linked to local variation in DNA methylation levels. No differences in methylation patterns were observed in urban-dwelling migrants compared to their non-migrant rural-dwelling siblings in India.Conclusions: Analysis of DNA methylation at three type 2 diabetes susceptibility loci highlighted geographical and ethnic differences in methylation patterns. These differences may be attributed to genetic and/or region-specific environmental factors.",

author = "Elliott, {Hannah R} and Walia, {Gagandeep Kaur} and Aparna Duggirala and Alix Groom and Reddy, {S. Umakar} and Chandak, {Giriraj Ratan} and Vipin Gupta and Markku Laakso and Dekker, {Jacqueline M} and Mark Walker and Shah Ebrahim and {Davey Smith}, George and Relton, {Caroline L}",

year = "2013",

doi = "10.7243/2050-0866-2-6",

language = "English",

journal = "Diabetes Research & Clinical Metabolism",

issn = "2050-0866",

}

Elliott, HR, Walia, GK, Duggirala, A, Groom, A, Reddy, SU, Chandak, GR, Gupta, V, Laakso, M, Dekker, JM, Walker, M, Ebrahim, S, Davey Smith, G & Relton, CL 2013, 'Migration and DNA methylation: a comparison of methylation patterns in type 2 diabetes susceptibility genes between indians and europeans', Diabetes Research & Clinical Metabolism. https://doi.org/10.7243/2050-0866-2-6

TY - JOUR

T1 - Migration and DNA methylation: a comparison of methylation patterns in type 2 diabetes susceptibility genes between indians and europeans

AU - Elliott, Hannah R

AU - Walia, Gagandeep Kaur

AU - Duggirala, Aparna

AU - Groom, Alix

AU - Reddy, S. Umakar

AU - Chandak, Giriraj Ratan

AU - Gupta, Vipin

AU - Laakso, Markku

AU - Dekker, Jacqueline M

AU - Walker, Mark

AU - Ebrahim, Shah

AU - Davey Smith, George

AU - Relton, Caroline L

PY - 2013

Y1 - 2013

N2 - Background: Type 2 diabetes is a global problem that is increasingly prevalent in low and middle income countries including India, and is partly attributed to increased urbanisation. Genotype clearly plays a role in type 2 diabetes susceptibility. However, the role of DNA methylation and its interaction with genotype and metabolic measures is poorly understood. This study aimed to establish whether methylation patterns of type 2 diabetes genes differ between distinct Indian and European populations and/or change following rural to urban migration in India.Methods: Quantitative DNA methylation analysis in Indians and Europeans using Sequenom® EpiTYPER® technology was undertaken in three genes: ADCY5, FTO and KCNJ11. Metabolic measures and genotype data were also analysed.Results: Consistent differences in DNA methylation patterns were observed between Indian and European populations in ADCY5, FTO and KCNJ11. Associations were demonstrated between FTO rs9939609 and BMI and between ADCY5 rs17295401 and HDL levels in Europeans. However, these observations were not linked to local variation in DNA methylation levels. No differences in methylation patterns were observed in urban-dwelling migrants compared to their non-migrant rural-dwelling siblings in India.Conclusions: Analysis of DNA methylation at three type 2 diabetes susceptibility loci highlighted geographical and ethnic differences in methylation patterns. These differences may be attributed to genetic and/or region-specific environmental factors.

AB - Background: Type 2 diabetes is a global problem that is increasingly prevalent in low and middle income countries including India, and is partly attributed to increased urbanisation. Genotype clearly plays a role in type 2 diabetes susceptibility. However, the role of DNA methylation and its interaction with genotype and metabolic measures is poorly understood. This study aimed to establish whether methylation patterns of type 2 diabetes genes differ between distinct Indian and European populations and/or change following rural to urban migration in India.Methods: Quantitative DNA methylation analysis in Indians and Europeans using Sequenom® EpiTYPER® technology was undertaken in three genes: ADCY5, FTO and KCNJ11. Metabolic measures and genotype data were also analysed.Results: Consistent differences in DNA methylation patterns were observed between Indian and European populations in ADCY5, FTO and KCNJ11. Associations were demonstrated between FTO rs9939609 and BMI and between ADCY5 rs17295401 and HDL levels in Europeans. However, these observations were not linked to local variation in DNA methylation levels. No differences in methylation patterns were observed in urban-dwelling migrants compared to their non-migrant rural-dwelling siblings in India.Conclusions: Analysis of DNA methylation at three type 2 diabetes susceptibility loci highlighted geographical and ethnic differences in methylation patterns. These differences may be attributed to genetic and/or region-specific environmental factors.

U2 - 10.7243/2050-0866-2-6

DO - 10.7243/2050-0866-2-6

M3 - Article (Academic Journal)

C2 - 27099715

SN - 2050-0866

JO - Diabetes Research & Clinical Metabolism

JF - Diabetes Research & Clinical Metabolism

ER -

Migration and DNA methylation: a comparison of methylation patterns in type 2 diabetes susceptibility genes between indians and europeans

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MRC UoB UNITE Unit - Programme 2

CENTRE FOR CASUAL ANALYSES IN TRANSLATIONAL EPIDEMIOLOGY (CAiTE)

Cite this