The urinary bladder generates spontaneous contractile activity (SA) to maintain bladder wall tone but remains compliant during filling. SA is greater in isolated preparations from patients with overactive bladder (OAB) and may underlie the associated symptoms. Due to significant refractoriness and adverse side-effects of drug-based therapies, new approaches to alleviate the symptoms of OAB are desirable. One approach may be through mild heating of the bladder wall.
- overactive bladder
- spontaneous contractions