Mimicking the Phenomenon of Ischemic Preconditioning by Actions on Cannabinoid Receptors: The Roles of Protein Kinase C and NO Synthase

Yu B. Lishmanov*, L. N. Maslov, A. V. Krylatov, Igor Khaliulin

*Corresponding author for this work

Research output: Contribution to journalArticle (Academic Journal)peer-review

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Abstract

Stimulation of CB1 receptors was found to mimic the phenomenon of preconditioning. As the cardioprotective effect of the cannabinoid HU-210 is seen in both in vivo experiments and in vitro studies, there are grounds for suggesting that the protective effects of HU-210 are mediated by activation of cardiac CB1 receptors. The cardioprotective effect of the cannabinoid HU-210 was found to be linked with stimulation of protein kinase C, while NO synthase has no role in the protective action of stimulation of CB1 receptors.
Translated title of the contributionMimicking the Phenomenon of Ischemic Preconditioning by Actions on Cannabinoid Receptors: The Roles of Protein Kinase C and NO Synthase
Original languageRussian
Pages (from-to)25-32
Number of pages8
JournalNeuroscience and Behavioral Physiology
Volume47
Issue number1
Early online date16 Nov 2016
DOIs
Publication statusPublished - 1 Jan 2017

Bibliographical note

N.b. accepted manuscript is written in the original Russian.

Keywords

  • cannabinoids
  • heart
  • ischemia
  • NO synthase
  • preconditioning
  • protein kinase C
  • reperfusion

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