Stimulation of CB1 receptors was found to mimic the phenomenon of preconditioning. As the cardioprotective effect of the cannabinoid HU-210 is seen in both in vivo experiments and in vitro studies, there are grounds for suggesting that the protective effects of HU-210 are mediated by activation of cardiac CB1 receptors. The cardioprotective effect of the cannabinoid HU-210 was found to be linked with stimulation of protein kinase C, while NO synthase has no role in the protective action of stimulation of CB1 receptors.
|Translated title of the contribution||Mimicking the Phenomenon of Ischemic Preconditioning by Actions on Cannabinoid Receptors: The Roles of Protein Kinase C and NO Synthase|
|Number of pages||8|
|Journal||Neuroscience and Behavioral Physiology|
|Early online date||16 Nov 2016|
|Publication status||Published - 1 Jan 2017|
Bibliographical noteN.b. accepted manuscript is written in the original Russian.
- NO synthase
- protein kinase C