Globally, harmful drinking results in six deaths every minute. The evidence indicates that restricting the availability of alcohol, and early identification and brief advice (IBA) are effective interventions to reduce alcohol harm. Furthermore, recent work suggests that there is a need to engage communities in actions to reduce alcohol harm. In order to tackle the high social and economic cost of alcohol, estimated to be £1.3 bn per year or £500 per resident, the UK city region of Greater Manchester (GM) implemented an innovative programme to reduce alcohol harm in September 2017. This asset- and place- based community development approach – called Communities in Charge of Alcohol (CICA) – aims to reduce alcohol harm in specific deprived areas across 10 local authorities.