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Modeling Podocyte Biology Using Drosophila Nephrocytes

Research output: Chapter in Book/Report/Conference proceedingChapter in a book

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Modeling Podocyte Biology Using Drosophila Nephrocytes. / Hartley, Paul S; Coward, Richard J.

Modeling Podocyte Biology using Drosophila Nephrocytes. Vol. 2067 Springer, 2020. p. 11-24 (Methods in Molecular Biology).

Research output: Chapter in Book/Report/Conference proceedingChapter in a book

Harvard

Hartley, PS & Coward, RJ 2020, Modeling Podocyte Biology Using Drosophila Nephrocytes. in Modeling Podocyte Biology using Drosophila Nephrocytes. vol. 2067, Methods in Molecular Biology, Springer, pp. 11-24. https://doi.org/10.1007/978-1-4939-9841-8_2

APA

Hartley, P. S., & Coward, R. J. (2020). Modeling Podocyte Biology Using Drosophila Nephrocytes. In Modeling Podocyte Biology using Drosophila Nephrocytes (Vol. 2067, pp. 11-24). (Methods in Molecular Biology). Springer. https://doi.org/10.1007/978-1-4939-9841-8_2

Vancouver

Hartley PS, Coward RJ. Modeling Podocyte Biology Using Drosophila Nephrocytes. In Modeling Podocyte Biology using Drosophila Nephrocytes. Vol. 2067. Springer. 2020. p. 11-24. (Methods in Molecular Biology). https://doi.org/10.1007/978-1-4939-9841-8_2

Author

Hartley, Paul S ; Coward, Richard J. / Modeling Podocyte Biology Using Drosophila Nephrocytes. Modeling Podocyte Biology using Drosophila Nephrocytes. Vol. 2067 Springer, 2020. pp. 11-24 (Methods in Molecular Biology).

Bibtex

@inbook{8004b2a764e341e79f10815497be9d01,
title = "Modeling Podocyte Biology Using Drosophila Nephrocytes",
abstract = "Vertebrate podocytes are kidney glomerular cells critically required for normal renal filtration. To fulfill their role, podocytes form molecular sieves known as slit diaphragms that contribute to the glomerular filtration barrier. The disruption of podocyte biology or slit diaphragm formation in humans is a precursor to albuminuria, renal failure, and cardiovascular morbidity. Due to genetic and functional similarities, the nephrocytes of Drosophila are increasingly used to model the genetic and metabolic basis of human podocyte biology. They have the advantage that they are a much quicker system to study compared to other murine transgenic models. In this chapter we present methods to modulate and study Drosophila nephrocyte function and diaphragm formation.",
author = "Hartley, {Paul S} and Coward, {Richard J}",
year = "2020",
doi = "10.1007/978-1-4939-9841-8_2",
language = "English",
volume = "2067",
series = "Methods in Molecular Biology",
publisher = "Springer",
pages = "11--24",
booktitle = "Modeling Podocyte Biology using Drosophila Nephrocytes",

}

RIS - suitable for import to EndNote

TY - CHAP

T1 - Modeling Podocyte Biology Using Drosophila Nephrocytes

AU - Hartley, Paul S

AU - Coward, Richard J

PY - 2020

Y1 - 2020

N2 - Vertebrate podocytes are kidney glomerular cells critically required for normal renal filtration. To fulfill their role, podocytes form molecular sieves known as slit diaphragms that contribute to the glomerular filtration barrier. The disruption of podocyte biology or slit diaphragm formation in humans is a precursor to albuminuria, renal failure, and cardiovascular morbidity. Due to genetic and functional similarities, the nephrocytes of Drosophila are increasingly used to model the genetic and metabolic basis of human podocyte biology. They have the advantage that they are a much quicker system to study compared to other murine transgenic models. In this chapter we present methods to modulate and study Drosophila nephrocyte function and diaphragm formation.

AB - Vertebrate podocytes are kidney glomerular cells critically required for normal renal filtration. To fulfill their role, podocytes form molecular sieves known as slit diaphragms that contribute to the glomerular filtration barrier. The disruption of podocyte biology or slit diaphragm formation in humans is a precursor to albuminuria, renal failure, and cardiovascular morbidity. Due to genetic and functional similarities, the nephrocytes of Drosophila are increasingly used to model the genetic and metabolic basis of human podocyte biology. They have the advantage that they are a much quicker system to study compared to other murine transgenic models. In this chapter we present methods to modulate and study Drosophila nephrocyte function and diaphragm formation.

U2 - 10.1007/978-1-4939-9841-8_2

DO - 10.1007/978-1-4939-9841-8_2

M3 - Chapter in a book

VL - 2067

T3 - Methods in Molecular Biology

SP - 11

EP - 24

BT - Modeling Podocyte Biology using Drosophila Nephrocytes

PB - Springer

ER -