Projects per year
Abstract
In rodents and humans the liver can restore its mass after hepatectomy efficiently. This is largely attributed to the proliferation and cell cycle re-entry of hepatocytes. On the other hand, bone marrow cells (BMCs) migrate into the liver after resection. Here we find that a block of BMC recruitment into the liver severely impairs its regeneration after the surgery. Mobilized hematopoietic stem and progenitor cells (HSPCs) in the resected liver can fuse with hepatocytes and the hybrids proliferate earlier than the hepatocytes. Genetic ablation of the hybrids severely impairs hepatocyte proliferation and liver mass regeneration. Mathematical modelling reveals a key role of BM-derived hybrids to drive proliferation in the regeneration process, and predicts regeneration efficiency in experimentally nontestable conditions. In conclusion, BM-derived hybrids are essential to trigger efficient liver regeneration after hepatectomy.
Original language | English |
---|---|
Pages (from-to) | 107-121 |
Number of pages | 15 |
Journal | Cell Reports |
Volume | 18 |
Issue number | 1 |
DOIs | |
Publication status | Published - 3 Jan 2017 |
Bibliographical note
Accepted 1 Dec 2016Structured keywords
- BrisSynBio
- Bristol BioDesign Institute
Keywords
- cell fusion
- mathematical modeling
- liver regeneration
- partial hepatectomy
- hematopoietic stem cells
- cell migration
- cell recruitment
- proliferation
- systems biology
Fingerprint
Dive into the research topics of 'Modelling dynamics and function of bone marrow cells in mouse liver regeneration'. Together they form a unique fingerprint.Projects
- 1 Finished
-
Unravelling the role of beta-catenin in ground state pluripotency
1/09/16 → 29/02/20
Project: Research
Profiles
-
Dr Lucia Marucci
- School of Engineering Mathematics and Technology - Associate Professor in Systems and Synthetic Biology
Person: Academic