Modelling multiple sources of dissemination bias in meta-analysis

Jack Bowden*, Dan Jackson, Simon G. Thompson

*Corresponding author for this work

Research output: Contribution to journalArticle (Academic Journal)

13 Citations (Scopus)

Abstract

Asymmetry in the funnel plot for a meta-analysis suggests the presence of dissemination bias. This may be caused by publication bias through the decisions of journal editors, by selective reporting of research results by authors or by a combination of both. Typically, study results that are statistically significant or have larger estimated effect sizes are more likely to appear in the published literature, hence giving a biased picture of the evidence-base. Previous statistical approaches for addressing dissemination bias have assumed only a single selection mechanism. Here we consider a more realistic scenario in which multiple dissemination processes, involving both the publishing authors and journals, are operating. In practical applications, the methods can be used to provide sensitivity analyses for the potential effects of multiple dissemination biases operating in meta-analysis.

Original languageEnglish
Pages (from-to)945-955
Number of pages11
JournalStatistics in Medicine
Volume29
Issue number7-8
DOIs
Publication statusPublished - Mar 2010

Keywords

  • Dissemination bias
  • Dissemination route
  • Meta-analysis
  • Monte carlo sensitivity analysis

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