Modelling the role of Tax expression in HTLV-I persistence in vivo

Michael Y Li, Aaron G Lim

Research output: Contribution to journalArticle (Academic Journal)peer-review

19 Citations (Scopus)

Abstract

Human T-lymphotropic virus type I (HTLV-I) is a persistent human retrovirus characterized by life-long infection and risk of developing HAM/TSP, a progressive neurological and inflammatory disease, and adult T-cell leukemia (ATL). Chronically infected individuals often harbor high proviral loads despite maintaining a persistently activated immune response. Based on a new hypothesis for the persistence of HTLV-I infection, a three-dimensional compartmental model is constructed that describes the dynamic interactions among latently infected target cells, target-cell activation, and immune responses to HTLV-I, with an emphasis on understanding the role of Tax expression in the persistence of HTLV-I.

Original languageEnglish
Pages (from-to)3008-29
Number of pages22
JournalBulletin of Mathematical Biology
Volume73
Issue number12
DOIs
Publication statusPublished - Dec 2011

Keywords

  • Adult
  • Gene Expression
  • Gene Products, tax
  • Genes, pX
  • HTLV-I Infections
  • Human T-lymphotropic virus 1
  • Humans
  • Mathematical Concepts
  • Models, Biological
  • Viral Load

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