Abstract
A modular Rh-catalyzed entry to azepines is outlined. Under a CO atmosphere, protecting group directed C–C bond activation of aminocyclopropanes provides rhodacyclopentanones. These intermediates are effective for intramolecular C–H metalation of either an N-aryl or N-vinyl unit en route to azepine ring systems. Thus, byproduct-free heterocyclizations are enabled by sequential C–C activation and C–H functionalization steps.
Original language | English |
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Pages (from-to) | 2743-2747 |
Number of pages | 5 |
Journal | Journal of the American Chemical Society |
Volume | 140 |
Issue number | 8 |
Early online date | 20 Feb 2018 |
DOIs | |
Publication status | Published - 28 Feb 2018 |