Modular Access to Azepines by Directed Carbonylative C-C Bond Activation of Aminocyclopropanes

Gangwei Wang, John Bower

Research output: Contribution to journalArticle (Academic Journal)peer-review

37 Citations (Scopus)
270 Downloads (Pure)

Abstract

A modular Rh-catalyzed entry to azepines is outlined. Under a CO atmosphere, protecting group directed C–C bond activation of aminocyclopropanes provides rhodacyclopentanones. These intermediates are effective for intramolecular C–H metalation of either an N-aryl or N-vinyl unit en route to azepine ring systems. Thus, byproduct-free heterocyclizations are enabled by sequential C–C activation and C–H functionalization steps.
Original languageEnglish
Pages (from-to)2743-2747
Number of pages5
JournalJournal of the American Chemical Society
Volume140
Issue number8
Early online date20 Feb 2018
DOIs
Publication statusPublished - 28 Feb 2018

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