Projects per year
Abstract
A short entry to substituted azocanes by a Rh-catalyzed cycloadditio −fragmentation process is described. Specifically, exposure of diverse N-cyclopropylacrylamides to phosphine-ligated cationic Rh(I) catalyst systems under a CO atmosphere enables the directed generation of rhodacyclopentanone intermediates. Subsequent insertion of the alkene component is followed by fragmentation to give the heterocyclic target. Stereochemical studies show, for the first time, that alkene insertion into rhodacyclopentanones can be reversible.
Original language | English |
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Pages (from-to) | 8054-8057 |
Number of pages | 4 |
Journal | Journal of the American Chemical Society |
Volume | 137 |
Issue number | 25 |
DOIs | |
Publication status | Published - 19 Jun 2015 |
Structured keywords
- BCS and TECS CDTs
Fingerprint Dive into the research topics of 'Modular access to substituted azocanes via a rhodium-catalyzed cycloaddition-fragmentation strategy'. Together they form a unique fingerprint.
Projects
- 2 Finished
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CatHet: CatHet: New catalytic asymmetric strategies for N-heterocycle synthesis
Barry, L. S.
1/04/15 → 31/03/20
Project: Research
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