Modular design of peptide fibrillar nano- to microstructures

MG Ryadnov, A Bella, S Timson, DN Woolfson

Research output: Contribution to journalArticle (Academic Journal)peer-review

40 Citations (Scopus)

Abstract

A general concept for designing self-assembling peptide fibrillar nano- to microstructures is described. The approach relies on the use of straightforward α-helical one-heptad (1 nm) modules without the need for more-specific designs. Various combinations of the modules gave a variety of constructs that were examined by a combination of spectroscopy and microscopy. These show that simple rearrangements and stereochemical conversions of the modules within similar templates lead to different fiber morphologies. The concept opens new strategies for designing fibrous materials with tunable properties at the nanoscale.
Translated title of the contributionModular design of peptide fibrillar nano- to microstructures
Original languageEnglish
Pages (from-to)13240 - 13241
Number of pages2
JournalJournal of the American Chemical Society
Volume131 (37)
DOIs
Publication statusPublished - Sep 2009

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