Abstract
The DOME is a powerful and adaptable platform that facilitates the study of light-reactive systems at the microscale. While the projection module of the DOME can produce light patterns with high spatial and temporal resolution, the maximum irradiance (incident electromagnetic energy per unit area) that can be generated by its native LEDs is limited. Increasing the irradiance is crucial to enabling new biomedical applications such as inducing DNA damage. In this paper, we present a modular solution to allow general light sources to be used with the DOME. By switching to a high-powered near-UV light source, we show that DNA damage can be caused by the Epi-DOME's projection system at a targeted location.
Original language | English |
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DOIs | |
Publication status | Published - 7 Nov 2023 |
Event | MARSS 2023 Conference - Abu Dhabi, United Arab Emirates Duration: 9 Oct 2023 → 13 Oct 2023 |
Conference
Conference | MARSS 2023 Conference |
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Country/Territory | United Arab Emirates |
City | Abu Dhabi |
Period | 9/10/23 → 13/10/23 |
Bibliographical note
Funding Information:This work is supported by the EPSRC Digital Health and Care Centre for Doctoral Training (CDT) (UKRI Grant No. EP/S023704/1) (N.W), the EPSRC Future Autonomous, and Robotic Systems Centre for Doctoral Training (FARSCOPE) (UKRI Grant No. EP/S021795/1) (M.U), the Royal Society Fellowship (URF/R/201021) (M.J.H), Cancer Research UK Programme Foundation Award (Grant C38607/A26831) (E.P), a Wellcome Trust Senior Research Fellowship (205010/Z/16/Z) (E.P), an EU grant No. 101070918 (S.H) and UKRI grant No. 10038942 (S.H).
Publisher Copyright:
© 2023 IEEE.