Modular Wavelength Adaptation of the Dynamic Optical MicroEnvironment

Neshika S Wijewardhane; Matthew Uppington; Martin J How; Helmut Hauser; Eugenia Piddini; Sabine Hauert

doi:10.1109/MARSS58567.2023.10294114

Modular Wavelength Adaptation of the Dynamic Optical MicroEnvironment

Neshika S Wijewardhane^*, Matthew Uppington, Martin J How, Helmut Hauser, Eugenia Piddini, Sabine Hauert

^*Corresponding author for this work

Research output: Contribution to conference › Conference Paper › peer-review

Abstract

The DOME is a powerful and adaptable platform that facilitates the study of light-reactive systems at the microscale. While the projection module of the DOME can produce light patterns with high spatial and temporal resolution, the maximum irradiance (incident electromagnetic energy per unit area) that can be generated by its native LEDs is limited. Increasing the irradiance is crucial to enabling new biomedical applications such as inducing DNA damage. In this paper, we present a modular solution to allow general light sources to be used with the DOME. By switching to a high-powered near-UV light source, we show that DNA damage can be caused by the Epi-DOME's projection system at a targeted location.

Original language	English
DOIs	https://doi.org/10.1109/MARSS58567.2023.10294114
Publication status	Published - 7 Nov 2023
Event	MARSS 2023 Conference - Abu Dhabi, United Arab Emirates Duration: 9 Oct 2023 → 13 Oct 2023

Conference

Conference	MARSS 2023 Conference
Country/Territory	United Arab Emirates
City	Abu Dhabi
Period	9/10/23 → 13/10/23

Bibliographical note

Funding Information:
This work is supported by the EPSRC Digital Health and Care Centre for Doctoral Training (CDT) (UKRI Grant No. EP/S023704/1) (N.W), the EPSRC Future Autonomous, and Robotic Systems Centre for Doctoral Training (FARSCOPE) (UKRI Grant No. EP/S021795/1) (M.U), the Royal Society Fellowship (URF/R/201021) (M.J.H), Cancer Research UK Programme Foundation Award (Grant C38607/A26831) (E.P), a Wellcome Trust Senior Research Fellowship (205010/Z/16/Z) (E.P), an EU grant No. 101070918 (S.H) and UKRI grant No. 10038942 (S.H).

Publisher Copyright:
© 2023 IEEE.

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title = "Modular Wavelength Adaptation of the Dynamic Optical MicroEnvironment",

abstract = "The DOME is a powerful and adaptable platform that facilitates the study of light-reactive systems at the microscale. While the projection module of the DOME can produce light patterns with high spatial and temporal resolution, the maximum irradiance (incident electromagnetic energy per unit area) that can be generated by its native LEDs is limited. Increasing the irradiance is crucial to enabling new biomedical applications such as inducing DNA damage. In this paper, we present a modular solution to allow general light sources to be used with the DOME. By switching to a high-powered near-UV light source, we show that DNA damage can be caused by the Epi-DOME's projection system at a targeted location.",

author = "Wijewardhane, {Neshika S} and Matthew Uppington and How, {Martin J} and Helmut Hauser and Eugenia Piddini and Sabine Hauert",

note = "Funding Information: This work is supported by the EPSRC Digital Health and Care Centre for Doctoral Training (CDT) (UKRI Grant No. EP/S023704/1) (N.W), the EPSRC Future Autonomous, and Robotic Systems Centre for Doctoral Training (FARSCOPE) (UKRI Grant No. EP/S021795/1) (M.U), the Royal Society Fellowship (URF/R/201021) (M.J.H), Cancer Research UK Programme Foundation Award (Grant C38607/A26831) (E.P), a Wellcome Trust Senior Research Fellowship (205010/Z/16/Z) (E.P), an EU grant No. 101070918 (S.H) and UKRI grant No. 10038942 (S.H). Publisher Copyright: {\textcopyright} 2023 IEEE.; MARSS 2023 Conference ; Conference date: 09-10-2023 Through 13-10-2023",

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AU - Wijewardhane, Neshika S

AU - Uppington, Matthew

AU - How, Martin J

AU - Hauser, Helmut

AU - Piddini, Eugenia

AU - Hauert, Sabine

N1 - Funding Information: This work is supported by the EPSRC Digital Health and Care Centre for Doctoral Training (CDT) (UKRI Grant No. EP/S023704/1) (N.W), the EPSRC Future Autonomous, and Robotic Systems Centre for Doctoral Training (FARSCOPE) (UKRI Grant No. EP/S021795/1) (M.U), the Royal Society Fellowship (URF/R/201021) (M.J.H), Cancer Research UK Programme Foundation Award (Grant C38607/A26831) (E.P), a Wellcome Trust Senior Research Fellowship (205010/Z/16/Z) (E.P), an EU grant No. 101070918 (S.H) and UKRI grant No. 10038942 (S.H). Publisher Copyright: © 2023 IEEE.

PY - 2023/11/7

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N2 - The DOME is a powerful and adaptable platform that facilitates the study of light-reactive systems at the microscale. While the projection module of the DOME can produce light patterns with high spatial and temporal resolution, the maximum irradiance (incident electromagnetic energy per unit area) that can be generated by its native LEDs is limited. Increasing the irradiance is crucial to enabling new biomedical applications such as inducing DNA damage. In this paper, we present a modular solution to allow general light sources to be used with the DOME. By switching to a high-powered near-UV light source, we show that DNA damage can be caused by the Epi-DOME's projection system at a targeted location.

AB - The DOME is a powerful and adaptable platform that facilitates the study of light-reactive systems at the microscale. While the projection module of the DOME can produce light patterns with high spatial and temporal resolution, the maximum irradiance (incident electromagnetic energy per unit area) that can be generated by its native LEDs is limited. Increasing the irradiance is crucial to enabling new biomedical applications such as inducing DNA damage. In this paper, we present a modular solution to allow general light sources to be used with the DOME. By switching to a high-powered near-UV light source, we show that DNA damage can be caused by the Epi-DOME's projection system at a targeted location.

U2 - 10.1109/MARSS58567.2023.10294114

DO - 10.1109/MARSS58567.2023.10294114

M3 - Conference Paper

T2 - MARSS 2023 Conference

Y2 - 9 October 2023 through 13 October 2023

ER -

Modular Wavelength Adaptation of the Dynamic Optical MicroEnvironment

Abstract

Conference

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