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Abstract
Salient events activate the midbrain dopaminergic system and have important impacts on various aspects of mnemonic function, including the stability of hippocampus-dependent memories. Dopamine is also central to modulation of neocortical memory processing, particularly during prefrontal cortex-dependent working memory. Here, we review the current state of the circuitry and physiology underlying dopamine's actions, suggesting that--alongside local effects within hippocampus and prefrontal cortex--dopamine released from the midbrain ventral tegmental area is well positioned to dynamically tune interactions between limbic-cortical circuits through modulation of rhythmic network activity.
Original language | English |
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Title of host publication | The Connected Hippocampus |
Editors | Shane O'Mara, Marian Tsanov |
Publisher | Amsterdam:Elsevier |
Pages | 187-216 |
Number of pages | 30 |
ISBN (Print) | 9780444635495 |
DOIs | |
Publication status | Published - 2015 |
Publication series
Name | Progress in Brain Research |
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Publisher | Elsevier |
Volume | 219 |
ISSN (Print) | 0079-6123 |
ISSN (Electronic) | 1875-7855 |
Keywords
- Dopamine
- hippocampus
- prefrontal cortex
- learning and memory
- theta coherence
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Dive into the research topics of 'Modulating the map: dopaminergic tuning of hippocampal spatial coding and interactions'. Together they form a unique fingerprint.Projects
- 1 Finished
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SNCF: Control of cognitve networks
Jones, M. W. (Principal Investigator)
1/04/11 → 1/10/16
Project: Research