Modulating the map: dopaminergic tuning of hippocampal spatial coding and interactions

Emilie Werlen, Matt Jones

Research output: Chapter in Book/Report/Conference proceedingChapter in a book

11 Citations (Scopus)

Abstract

Salient events activate the midbrain dopaminergic system and have important impacts on various aspects of mnemonic function, including the stability of hippocampus-dependent memories. Dopamine is also central to modulation of neocortical memory processing, particularly during prefrontal cortex-dependent working memory. Here, we review the current state of the circuitry and physiology underlying dopamine's actions, suggesting that--alongside local effects within hippocampus and prefrontal cortex--dopamine released from the midbrain ventral tegmental area is well positioned to dynamically tune interactions between limbic-cortical circuits through modulation of rhythmic network activity.

Original languageEnglish
Title of host publicationThe Connected Hippocampus
EditorsShane O'Mara, Marian Tsanov
PublisherAmsterdam:Elsevier
Pages187-216
Number of pages30
ISBN (Print)9780444635495
DOIs
Publication statusPublished - 2015

Publication series

NameProgress in Brain Research
PublisherElsevier
Volume219
ISSN (Print)0079-6123
ISSN (Electronic)1875-7855

Keywords

  • Dopamine
  • hippocampus
  • prefrontal cortex
  • learning and memory
  • theta coherence

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