Molecular engineering of polymeric supra-amphiphiles

Yincheng Chang, Yang Jiao, Henry Symons, Jiangfei Xu, Charl FJ Faul, Xi Zhang

Research output: Contribution to journalReview article (Academic Journal)

30 Citations (Scopus)
108 Downloads (Pure)

Abstract

Polymeric supra-amphiphiles are amphiphiles that are fabricated by linking polymeric segments, or small molecules and polymeric segments, by noncovalent interactions or dynamic covalent bonds. Compared with conventional amphiphilic polymers, polymeric supra-amphiphiles possess the advantages of facile preparation to some extent and dynamic features. Moreover, polymeric supra-amphiphiles are endowed with richer structure and higher stability compared with small-molecule supra-amphiphiles. Owing to these properties, polymeric supra-amphiphiles have so far shown great promise as surfactants, nanocarriers and in therapies. In this tutorial review, recent work on polymeric supra-amphiphiles, from molecular architectures to functional assemblies, are presented and summarized. Different polymeric supra-amphiphile topologies and related applications are highlighted. By combining polymer chemistry with supramolecular chemistry and colloid science, we anticipate that the study of polymeric supra-amphiphiles will promote the continued development of the molecular engineering of functional supramolecular systems, and lead to applications, especially in drug delivery.
Original languageEnglish
Article numberDOI: 10.1039/c8cs00806j
Pages (from-to)989-1003
Number of pages15
JournalChemical Society Reviews
Volume48
Issue number4
Early online date25 Jan 2019
DOIs
Publication statusPublished - 25 Jan 2019

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    Chang, Y., Jiao, Y., Symons, H., Xu, J., Faul, C. FJ., & Zhang, X. (2019). Molecular engineering of polymeric supra-amphiphiles. Chemical Society Reviews, 48(4), 989-1003. [DOI: 10.1039/c8cs00806j]. https://doi.org/10.1039/C8CS00806J